SBIR PHASE I - TOPIC 243 "NOVEL AND IMPROVED METHODS TO MEASURE CANCER EPIGENETIC

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$148,989.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
N43CO0800064
Award Id:
94178
Agency Tracking Number:
N43CO0800064
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1080 W. HARBOR VIEW DR, COEURDALENE, ID, 83814
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
799285015
Principal Investigator:
WUSI MAKI
() -
Business Contact:
() -
garymaki@integratedmolecularsensors.com
Research Institution:
n/a
Abstract
The proposed work will advance methylation diagnosis through the creation of a nano electronic methylation detection system. Most methods currently used in the detection of CpG methylation at specific sites require a bisulfate treatment, PCR amplification and other conventional bio-molecular assays which are time-consuming and lack accuracy. Recently, nanowire field effect transistor based electronic devices have shown promising results in the detection of DNA molecules with attractive features of being lab el-free and ultra-sensitive. Based on the previous research by the proposing team in the development of nano-transistor biosensor for DNA methylation detection, it is proposed herein to develop integrated electronic devices for analyzing the DNA methylatio n profiles for cancer cells. Proposed research involves three areas: a) generate specific electronic signals to report DNA methylation events in numerous gene promoters simultaneously (PhaseI); b) improve nano-transistor design, fabrication quality and yie ld (Phase I); and c) develop integrated devices of nano-transistors with deep submicron electronics (Phase II). A unique molecular signal transduction system which transforms molecular recognition events into electronic signals will be used for multiple DN A detection. Nano-transistor detectors are coupled to a set of microelectronic devices specifically designed for molecular electronic charge detection.

* information listed above is at the time of submission.

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