SBIR Phase I: Development of non-toxic antifouling compounds targeting a key G-protein coupled receptor involved in settlement and metamorphosis of barnacles

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$124,400.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
0839550
Agency Tracking Number:
0839550
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MariCal, Inc.
400 Commercial St., Portland, ME, 04101
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
042269592
Principal Investigator:
Steven Jury
PhD
(207) 773-2500
sjury@marical.biz
Business Contact:
Steven Jury
PhD
(207) 773-2500
sjury@marical.biz
Research Institution:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase I project develops a novel, non-toxic, antifouling technology for the aquaculture industry. Unlike existing biocidal metal-based coatings, our technology is based on a class of compounds that inhibit the settlement, attachment, and/or metamorphosis of invertebrates on marine surfaces by modulating the activity of a specific nutrient-salinity sensing receptor found in fouling invertebrates. In initial testing, it was demonstrated that a class of compounds called calcimimetics act on these receptors and possess antifouling activity in barnacles in the lab and the field. These data will be refined utilizing a combination of approaches to identify antifoulants suitable for use in the aquaculture industry. Such a non-toxic antifouling system will either replace or dramatically reduce the metal content of current toxic alternatives. The broader impacts of this research are to benefit society by discovering a non-toxic solution to antifouling. This approach, if successful, will reduce the need for metal-based coatings that are toxic to many non-fouling organisms and to allow for increased aquaculture opportunities that are often in economically depressed areas. One of these areas is downeast Maine and as such this research is carried out in collaboration with the University of Maine. This partnership will form the basis for future private-public projects in Maine?s developing aquaculture industries.

* information listed above is at the time of submission.

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