BIOABSORBABLE GLASS FOR RADIATION TREATMENT OF ARTHRITIS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13687
Amount: $499,936.00
Phase: Phase II
Program: SBIR
Awards Year: 1993
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Mo-sci Corp.
Twitty Industrial Pk Mead Bldg, Po Box 2, Rolla, MO, 65401
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 John B Koen
 (314) 364-2338
Business Contact
Phone: () -
Research Institution
N/A
Abstract
PRESENT TREATMENT OF RHEUMATOID ARTHRITIS IS PERFORMED BY SEVERAL METHODS, WHICH INCLUDE ANTI-INFLAMMATORY AGENTS, STEROIDS, IMMUNOSUPPRESSIVE AND CYTOTOXIC AGENTS, RADIATION TREATMENT BY BEAM METHOD, AND SURGERY. EACH METHOD HAS ITS DRAWBACKS. OF THESE METHODS, RADIATION BEAM TREATMENT HAS BEEN SHOWN TO SUPPRESS THE INFLAMED SYNOVIUM AND PALLIATE THE PATIENT'S PAIN. THERE ARE, HOWEVER, ADVERSE EFFECTS TO SURROUNDING HARD AND SOFT TISSUE. THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A GLASS MATRIX CONTAINING AN ACTIVATABLE BETA-EMITTING ISOTOPE WITH A TREATMENT DISTANCE OF 1 TO 3 MM. WHEN INJECTED INTO THE JOINT, THE MICROSPHERES WILL PERMIT A LOCALIZED IRRADIATION OF THE DISEASED AREA, LEADING TO RESULTS COMPARABLE TO THAT PROVIDED BY SURGERY. ONCE THE RADIOACTIVITY HAS DECAYED, THE MICROSPHERES WILL DISSOLVE AND BE ABSORBED INTO THE BODYOVER A 3- TO 6-MONTH PERIOD.

* information listed above is at the time of submission.

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