Bioactive Calcium Phosphate Glasses for Hyperthermia

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
21969
Agency Tracking Number:
21969
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P. O. Box 2, Rolla, MO, 65401
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Yongren B. Peng
(314) 364-2338
Business Contact:
() -
Research Institution:
n/a
Abstract
A new family of bioactive iron calcium phosphate glasses will be evaluated as thermoseeds for hyperthermia of cancers, especially bone tumors. Through appropriate heat treatment and atmosphere control, the Fe3+/Fe2+ ratio can be adjusted to achieve the desired magnetic hysteresis. The heat generating characteristics of these glasses under external magnetic induction will be studied as a function of glass composition, processing, sample geometry and microstructure. One or more candidate glass compositions will be identified for use in Phase II study where such material will be used in various in vitro, in vivo evaluations. Glass composition formulation takes into account of magnetic properties, bioactivity and glass forming characteristics. An appropriate balance among these properties will make such glass ideal as filler to bone defects after curettage of bone tumors, as filler in bone cements, and at the same time it is used as thermoseeds. In addition, iron calcium phosphate glasses can be made resorbable.

* information listed above is at the time of submission.

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