Development of a Miniature Plasma Brush for Dental Clinical Applications

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$157,804.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43DE019041-01A1
Award Id:
93669
Agency Tracking Number:
DE019041
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1005 BROOK TROUT CT, COLUMBIA, MO, 65203
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
800407343
Principal Investigator:
MENG CHEN
(573) 234-6451
CHENMENG@NANOVAMED.COM
Business Contact:
HAO LI
() -
lihao@nanovamed.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Nanova, Inc. is developing a miniature non-thermal gas plasma brush that is operated in open air and can be used for dental cavity treatment and preparation in dental clinics. To date, preparation of dental cavities pr ior to filling relies on mechanical drilling or laser techniques, which cause discomforts and pain to patients due to mechanical stimulation (vibration) and heating of the dental nerve. These methods are often destructive, because plenty of healthy tissue must be removed to ensure a sufficient disinfection. Moreover, the clinical life time for posterior composite restorations using the current methods typically last only 6 - 8 years with 70% failures occur at the dentin-composite interface. Such interfacial failures often cause microleakage, sensitivity, recurrent caries, composite restoration removal and replacement, and eventually loss of the infected teeth after several repeated restorations due to the destructive preparation processes. In contrast, non-t hermal gas plasma treatment will be a painless, nondestructive, and tissue-saving method for dental cavity preparation because of its non-thermal and non-destructive nature, distinguished chemical reactivity, and rapid sterilizing capability. When applied to dental cavity treatment and preparation, non-thermal plasmas provides a unique opportunity to chemically activate dentin surface, thus to implement chemical bonding and enhance adhesion strength at dentin-composite interfaces, and consequently to increa se the longevity of dental restorations. Successful development of such a miniature plasma brush that is suitable to dental clinical applications could become a high-impact innovation in dentistry. PUBLIC HEALTH RELEVANCE: Nanova, Inc. is develop ing a miniature non-thermal gas plasma brush that is operated in open air and can be used for dental cavity treatment and preparation in dental clinics without causing discomforts to patients. Successful development of such a miniature plasma brush will en able us to apply plasma surface/interface engineering to dentin preparation for composite restorations with significantly improved clinical performance and durability, and could become a high-impact innovation in dentistry.

* information listed above is at the time of submission.

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