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TOPIC 372:DEVELOPMENT AND VALIDATION OF NON-MOUSE REAGENTS TO ENABLE PRECLINICAL DEVELOPMENT OF NOVEL THERAPEUTICS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91020C00018
Agency Tracking Number: 75N91020C00018-0-9999-0
Amount: $1,995,852.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 372
Solicitation Number: N/A
Timeline
Solicitation Year: 2020
Award Year: 2020
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10151 Pacific Mesa Blvd
SAN DIEGO, CA 92121-4329
United States
DUNS: 186489899
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Xiaomin Fan
 (858) 776-1507
 xfan@avantgen.com
Business Contact
 Xiaomin Fan
Phone: (858) 776-1507
Email: xfan@avantgen.com
Research Institution
N/A
Abstract

Dogs with naturally occurring cancers can serve as a better model system for evaluating novel cancer immuno-therapeutics than the traditional mouse model systems, and also provide a target patient group. However, use of canine cancer patients is currently limited by the availability of suitable reagents to monitor canine immune responses. The majority of commercially-available reagents for canine biomarkers are rabbit polyclonal reagents, which are not renewable and suffer from lot-lo-lot variability. Following their success in Phase I, here the company proposes to use their novel yeast rabbit antibody display platform to discover high affinity, highly specific rabbit monoclonal antibodies against an expanded panel of 26 canine biomarkers. In parallel, AvantGen plans to optimize the caninized anti-canine-PD-1 antibody isolated in Phase I as a canine immunotherapeutic, then perform a pilot study in pet dogs with lymphoma to assess its safety and efficacy as concurrent therapy with standard of care chemotherapy using the biomarker reagents generated during this project to assess in vivo immune responses to treatment. A successful outcome will result in a panel of high quality, well characterized, renewable reagents for canine biomarkers that will facilitate future development of immunotherapeutics plus provide a novel treatment for canine lymphoma.

* Information listed above is at the time of submission. *

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