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BioSENSE, for identification of allosteric transcription factor biosensors

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-19-P-0003
Agency Tracking Number: A18B-016-0082
Amount: $149,995.82
Phase: Phase I
Program: STTR
Solicitation Topic Code: A18B-T016
Solicitation Number: 18.B
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2018-12-12
Award End Date (Contract End Date): 2019-06-12
Small Business Information
953 Indiana St
San Francisco, CA 94107
United States
DUNS: 079761816
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Zachary Sun
 CEO, Co-Founder
 (646) 725-6686
 zach@synvitrobio.com
Business Contact
 Zachary Sun
Phone: (646) 725-6686
Email: zach@synvitrobio.com
Research Institution
 UW Madison
 Yang Du Yang Du
 
21 N. Park St. Suite 6401
Madison, WI 53715
United States

 (408) 821-7622
 Nonprofit College or University
Abstract

There is a need to develop affordable and specific biosensors to defend against current and future biological threats. Biological methods of detection have been evolved by nature to detect molecules at the micro-scale with flexible specificity and with downstream effectors. Advances in cell-free technology allow for deployment of biosensors on pH-strip-type paper, an affordable, robust, disposable, and highly portable format for Field use. Synvitrobio and UW Madison propose developing BioSENSE, a product built off of cell-free expression to produce allosteric transcription factor (aTF) biosensors to DoD-relevant molecules with turnaround of 2-months or less. BioSENSE combines computational aTF design with high-throughput cell-free expression to rapidly test design iterations for activity. In Phase I, we will show the development and use of BioSENSE to sense model molecules, as well as engineered ligands to detect toxins. The identified biosensors can be implemented on paper for deployable detection, or can be used within engineered cells. In Phase II, we will scale BioSENSE to develop biosensors towards DoD-defined molecules of interest.

* Information listed above is at the time of submission. *

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