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Malaria SHIELD™ Delivery System: Long-Term Malarial Chemoprophylactic Drug Releasing Implant

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-19-C-0038
Agency Tracking Number: A18B-022-0144
Amount: $149,999.78
Phase: Phase I
Program: STTR
Solicitation Topic Code: A18B-T022
Solicitation Number: 18.B
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-02-04
Award End Date (Contract End Date): 2019-09-03
Small Business Information
301 1st Street SW Suite 200
Roanoke, VA 24011
United States
DUNS: 627132913
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Yang Xu
 Principal Investigator
 (434) 220-4232
Business Contact
 Michael Pruzan
Phone: (540) 769-8430
Research Institution
 New York Blood Center
 Barry A. Greene Barry A. Greene
310 E. 67th Street
New York, NY 10021
United States

 (212) 570-3034
 Nonprofit College or University

Malaria infection and transmission is a continual threat to military and civilian communities across the world, but there are very low compliance rates with current preventative treatments due to gastrointestinal effects of anti-malarial medications, forgetfulness, and a low perception of risk. In order to address the need for a long-acting malaria treatment that bypasses the issue of compliance, Luna will develop the Malaria SHIELD™ (Sustained-release Hydrogel Injection with Encapsulated Layer-by-layer Drug) delivery system in the proposed program. The hydrogel-nanoparticle formulation, delivered via subcutaneous injection, will be designed to controllably degrade and release drug-loaded nanoparticles into surrounding tissue. In addition to being compatible with multiple therapeutic agents, the formulation will require no removal surgery. In Phase I, Luna will demonstrate the feasibility of this delivery system using in vitro models, and in Phase II will demonstrate the functionality of the system in in vivo malaria models.

* Information listed above is at the time of submission. *

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