Photoreactive nanofibers for biomolecule immobilization

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43EB005905-01
Agency Tracking Number: EB005905
Amount: $99,595.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: N/A
Solicitation Number: PHS2006-2
Small Business Information
INNOVATIVE SURFACE TECHNOLOGIES, LLC, 1000 WESTGATE DR, STE 260, ST. PAUL, MN, 55114
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PATRICK GUIRE
 (651) 209-9757
 pguire@isurtec.com
Business Contact
 WAYNE VANDER VORT
Phone: (851) 209-9758
Email: WVANDERVORT@ISURTEC.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): This SBIR project is designed to demonstrate and develop an improved composition for nanofibers especially suitable for surface modification and biomolecule binding for cell culture and tissue engineering applications. A new trifunctional photoactivatible crosslinker will be included with available biodegradable polymers to form nanofibers containing photogroups on the surface. Rapid and facile illumination will enable photochemical bonding to the fiber surfaces, to the polymers suitable for biomolecule immobilization or the biomolecules themselves without polymeric spacers. The Phase II work is expected to develop biodegradable scaffolds for tissue engineering, more biomimetic cell culture surfaces for cellomic and other living cell sensor systems providing more confident assessment of toxicity and pharmaceutical activities in drug development. Specific aims of this Phase I proposal include: 1) optimize the electrospinning conditions for preparing photoreactive polymer nanofibers; 2) demonstrate facile surface modification of the photoreactive nanofibers with biomolecule-binding spacer polymers; and 3) demonstrate and optimize immobilization on the nanofibers of a model protein, streptavidin, with superior functional loading density.

* Information listed above is at the time of submission. *

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