Kidney Multiphoton Analysis of Therapeutic Agents

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2007
Program:
STTR
Phase:
Phase I
Contract:
1R41DK076478-01A1
Agency Tracking Number:
DK076478
Solicitation Year:
2007
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
INPHOTON, LLC
INPHOTON, LLC, 1213 ALDERLEY RD, INDIANAPOLIS, IN, 46260
Hubzone Owned:
N
Socially and Economically Disadvantaged:
Y
Woman Owned:
Y
Duns:
612993936
Principal Investigator:
KENNETH DUNN
(317) 278-0436
KWDUNN@IUPUI.EDU
Business Contact:
(630) 217-2402
satkinso@iupui.edu
Research Institution:
INDIANA UNIVERSITY

INDIANA UNIVERSITY
BRYAN HALL
BLOOMINGTON, IN, 47405 4899

Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): The integrated scientific team of INphoton, LLC will develop standard operating procedures for intravital multiphoton microscopy assays quantifying fluorescent drug delivery, cellular uptake, intracellular distribution, metabolism, and physiologic/therapeutic effects within the kidney of live rats. Refinement of some existing assays will be necessary for commercial utilization. The resulting products will enable INphoton to extend commercial services to pharmaceutical and biotech companies to enhance preclinical evaluation of potential products. INphoton, LLC will commercialize multiphoton microscopy for preclinical drug evaluation in the kidney. This will greatly aid evaluation of a potential therapeutic agent's cellular location, functional effects and adverse affects. Since this is not possible with other imaging modalities, this approach complements and extends existing imaging technologies.

* information listed above is at the time of submission.

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