Kidney Multiphoton Analysis of Therapeutic Agents

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41DK076478-01A1
Agency Tracking Number: DK076478
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
INPHOTON, LLC
INPHOTON, LLC, 1213 ALDERLEY RD, INDIANAPOLIS, IN, 46260
DUNS: 612993936
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 KENNETH DUNN
 (317) 278-0436
 KWDUNN@IUPUI.EDU
Business Contact
Phone: (630) 217-2402
Email: satkinso@iupui.edu
Research Institution
 INDIANA UNIVERSITY
 INDIANA UNIVERSITY
BRYAN HALL
BLOOMINGTON, IN, 47405 4899
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): The integrated scientific team of INphoton, LLC will develop standard operating procedures for intravital multiphoton microscopy assays quantifying fluorescent drug delivery, cellular uptake, intracellular distribution, metabolism, and physiologic/therapeutic effects within the kidney of live rats. Refinement of some existing assays will be necessary for commercial utilization. The resulting products will enable INphoton to extend commercial services to pharmaceutical and biotech companies to enhance preclinical evaluation of potential products. INphoton, LLC will commercialize multiphoton microscopy for preclinical drug evaluation in the kidney. This will greatly aid evaluation of a potential therapeutic agent's cellular location, functional effects and adverse affects. Since this is not possible with other imaging modalities, this approach complements and extends existing imaging technologies.

* information listed above is at the time of submission.

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