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Sodium/Proton Imaging for Assessment of Stroke Pathology

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43NS059089-01
Agency Tracking Number: NS059089
Amount: $99,510.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: 2007
Award Year: 2007
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
United States
DUNS: 153334086
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (508) 799-6464
Business Contact
Phone: (508) 799-6464
Research Institution

DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States and afflicts over 700,000 Americans each year. Treatment of acute ischemic attacks focuses on early intervention to minimize the degree of tissue loss in the brain. Magnetic resonance imaging (MRI) using proton based diffusion and perfusion techniques, has become an essential clinical service for evaluating the degree of stroke pathology. The capabilities of MRI in stroke evaluation would be enhanced by including sodium imaging. Tissue sodium concentration measured by sodium MRI would complement diffusion and perfusion MRI data by rapidly and directly evaluating regional tissue viability. Such data allows the identification of the volume of tissue that may be salvageable to be balanced objectively against the risk of hemorrhagic complications of thrombolysis by reperfusing already non-viable tissue. The present Phase I SBIR application proposes to develop a dual-tuned sodium/proton radiofrequency head coil at 3.0 Tesla for use in clinical service. This technology will be developed in three steps: 1) multi- conductor transmission line and finite element methods will be used to numerical simulate and optimize the electrical circuit design; 2) industry-standard mechanical CAD programming will be used to generate a 3-dimensional model of the coil and circuit layout, and 3) the coil will be evaluated for SNR, sodium quantification, spatial resolution, B1 homogeneity and acquisition times acceptable for sodium and proton imaging at 3.0 Tesla. The development of a robust, sodium/proton dual-tuned, head coil would help with the management, image acquisition, and diagnosis of critically ill stoke patients. The proposed technology will be used with MRI in a clinical service to diagnose, treat and manage critically ill stroke patients.

* Information listed above is at the time of submission. *

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