Heterogeneous Proteomics Data Analysis and Management

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HL079807-01
Agency Tracking Number: HL079807
Amount: $396,715.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: N/A
Solicitation Number: PHS2005-2
Small Business Information
Insilicos, 4509 Interlake Ave N, #223, Seattle, WA, 98103
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (206) 979-4832
Business Contact
Phone: (206) 965-9680
Research Institution
DESCRIPTION (provided by applicant): Software tools for statistical analysis arid comparison of proteomics data is proposed. Using these tools, data can be compared from different research groups using different experimental techniques, analytical instrumentation, peptide search engines, and databases. Proteomics can produce human health breakthroughs, but progress is hampered by the inability to directly compare and integrate results from different experiments. The proposed solution is a set of software tools permitting peptide identifications to be compared in a statistically-valid way, and permitting data to be readily exchanged between research groups. The research team includes leading experts in peptide search, proteomics databases, analysis of multidimensional chromatography, and scientific computing. The group has developed an extensive suite of proteomics software, which forms the foundation for this research. Collaborations give the team access to data from leading-edge proteomics experiments. Working with consortium partners, a heterogeneous proteomics data analysis and management system will be developed, base primarily on proteomics tools developed at the Institute for Systems Biology. We will extend the tools to support additional equipment and software systems, develop an integrated framework, and develop training materials and documentation. This system will be applicable to a range of proteomics analysis experiments, accelerating the adoption of new proteomics analysis techniques.

* information listed above is at the time of submission.

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