INTEGRAL MOLECULAR

Basic Information

3711 MARKET ST
PHILADELPHIA, PA, 19104-5504

http://www.integralmolecular.com

Company Profile

n/a

Additional Details

Field Value
DUNS: 034055645
Hubzone Owned: N
Socially and Economically Disadvantaged: N
Woman Owned: N
Number of Employees: 25


  1. Development of High-expressing Ion Channels for Research and Therapeutic Applicat

    Amount: $471,745.00

    DESCRIPTION (provided by applicant): Ion channels, such as Kv1.3 and Nav1.7, are involved in a number of human disorders, including autoimmunity and pain that affect gt100 million Americans annually a ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Engineering of membrane protein chemosensors for therapeutic research

    Amount: $1,213,215.00

    DESCRIPTION (provided by applicant): Cells require the ability to detect and respond to stimuli in their surroundings, including to endogenous metabolites, exogenous nutrients, and environmental irrit ...

    SBIR Phase II 2014 Department of Health and Human Services
  3. Development of P2X3 Ion Channel MAbs for the Treatment of Pain

    Amount: $1,428,459.00

    ABSTRACT Acute and chronic pain resulting from injury, surgery, or disease afflicts gt100 million Americans each year, having a severe impact on mood, mental health, and quality of life and costing th ...

    SBIR Phase II 2014 Department of Health and Human Services
  4. Engineering Stable, Soluble, and Trimeric HIV gp140 by Paired Cys Scanning

    Amount: $546,301.00

    DESCRIPTION (provided by applicant): When presented with a suitable antigenic Envelope (Env) structure, the human immune system can produce protective antibodies that HIV is unable to evade. Many of t ...

    SBIR Phase I 2012 Department of Health and Human Services
  5. Phage Display Isolation of Antibodies against Antigenically Conserved Membrane Pr

    Amount: $214,214.00

    DESCRIPTION (provided by applicant): We propose to use a novel technology, the Lipoparticle, to capture and concentrate structurally intact membrane proteins in a format amenable to phage panning for ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. High-throughput Epitope Mapping of Anti-Viral Antibodies

    Amount: $242,376.00

    DESCRIPTION (provided by applicant): The identification of highly potent and broadly neutralizing antibodies isolated from HIV-1- infected donors suggests that when presented with a suitable antigenic ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Isolation of Monoclonal Antibodies against Membrane Proteins

    Amount: $660,813.00

    DESCRIPTION (provided by applicant): Because of their importance in cell signaling and human disease, integral membrane proteins such as G protein-coupled receptors (GPCRs) and ion channels comprise o ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Development of taste receptor ligands using structure-activity studies

    Amount: $696,243.00

    DESCRIPTION (provided by applicant): As the primary mechanism by which animals detect nutrient-rich foods and discriminate against toxins, the sense of taste has a significant impact on health and beh ...

    SBIR Phase I 2009 Department of Health and Human Services
  9. Cell-free Detection of GPCR Signaling in a Nanoscale System

    Amount: $1,192,925.00

    DESCRIPTION (provided by applicant): G protein-coupled receptors (GPCRs) are one of the most important families of pharmaceutical targets. However, some of the most desirable types of GPCR drugs have ...

    SBIR Phase II 2008 Department of Health and Human Services
  10. Identification of Novel Influenza Inhibitors

    Amount: $599,243.00

    DESCRIPTION (provided by applicant): Influenza virus is a Category C biodefense pathogen of global public health concern because it causes 3-5 million cases of severe illness every year, and because o ...

    SBIR Phase I 2008 Department of Health and Human Services

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