Novel Multifunctional Probes

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43DE017459-01
Agency Tracking Number: DE017459
Amount: $100,366.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: N/A
Solicitation Number: PHS2005-2
Small Business Information
Integral Molecular, 3701 Market St, Ste 340, Philadelphia, PA, 19104
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 TIFFANI GREENE
 (215) 966-6067
 TGREENE@INTEGRALMOLECULAR.COM
Business Contact
 BENJAMIN DORANZ
Phone: (215) 966-6018
Email: BDORANZ@INTEGRALMOLECULAR.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Classical visual probes operate by binding to and illuminating a target molecule of interest. However, most probes are limited in response to a single event, binding to a single target, or reporting a single phenomenon. This is a significant limitation for imaging of cellular events, which are characterized by complex signaling pathways composed of multiple, spatially-localized signals. Current reporters have a second limitation for detection cellular function - they rarely permit intracellular localization for more accurate discrimination of signaling events. Probes that can be localized (e.g. antibodies) often cannot be amplified for the visualization of infrequent events. Probes that can be spatially localized at the nanometer scale and can link multiple reporters simultaneously could have a major impact on biomedical research and diagnostics. The difficulty in constructing better reporting systems is not simply the development of new reporters, but the ability to control existing reporters using suitable vehicles. Traditional vehicles (liposomes and beads) have been successful for some applications, but have difficulty incorporating enzymes and membrane proteins, are difficult to localize, and are often unstable. The purpose of this proposal is to create a new class of molecular probe that can detect targets with high sensitivity, nanometer-scale spatial resolution, and multiple detection modalities.

* Information listed above is at the time of submission. *

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