THE OVERALL OBJECTIVE OF THIS RESEARCH PLAN IS TO EVALUATE AND OPTIMIZE A NEW ANALYTICAL PROCEDURE (MICROGRAVIMETRIC IMMUNOASSAY) FOR THE DETECTION AND QUANTITATION OF AN IMPORTANT BRAIN PROTEIN, MYELIN BASIC PROTEIN, WITH PROJECT-ED UTILITY IN THE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
5305
Agency Tracking Number:
5305
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
44 Mechanic Street, Newton, MA, 02164
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR GLENN J BASTIAANS
PRINCIPAL INVESTIGATOR
(617) 965-6950
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OVERALL OBJECTIVE OF THIS RESEARCH PLAN IS TO EVALUATE AND OPTIMIZE A NEW ANALYTICAL PROCEDURE (MICROGRAVIMETRIC IMMUNOASSAY) FOR THE DETECTION AND QUANTITATION OF AN IMPORTANT BRAIN PROTEIN, MYELIN BASIC PROTEIN, WITH PROJECT-ED UTILITY IN THE DIAGNOSIS AND TREATMENT OF MULTIPLE SCLEROSIS AND ALZHEIMER'S DISEASE. THE DEVELOPMENT AND EVENTUAL COMMERCIALIZATION OF SUCH A METHODOLOGY COULD SIMPLIFY AND SPEED THE DIAGNOSIS OF A NUMBER OF MENTAL DISORDERS. THE RESEARCH PLAN INCLUDES THE CONSTRUCTION OF MICROELECTRONIC SENSORS BASED ON SURFACE ACOUSTIC WAVE TECHNOLOGY THAT INCORPORATES A POLYMER LAYER THAT PROTECTS THE SENSOR, REDUCES NONSPECIFIC BINDING, AND ALLOWS COVALENTCOUPLING OF MONOCLONAL ANTIBODIES. PROTOTYPE SENSORS WILL BE TESTED FOR FUNDAMENTAL OPERATIONAL CHARACTERISTICS. BIO- CHEMICAL REAGENTS INCLUDING MYELIN BASIC PROTEIN AND MONO- CLONAL ANTIBODIES TO THAT PROTEIN WILL BE PREPARED IN A PARALLEL PROGRAM. WHEN BOTH ARE READY, SENSORS INCORPORAT- ING THE MONOCLONAL ANTIBODIES WILL BE EVALUATED AND COMPAREDTO REFERENCE LABORATORY TECHNIQUES.

* information listed above is at the time of submission.

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