ELECTROPHORETIC DESORPTION FOR THE REGENERATION OF IMMUNOLOGICALLY ACTIVE SENSOR SURFACES

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$189,478.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
5977
Agency Tracking Number:
5977
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
44 Mechanic St, Newton, MA, 02164
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Glenn J Bastiaans
(617) 965-6950
Business Contact:
() -
Research Institute:
n/a
Abstract
THE PURPOSE OF THIS PROGRAM IS TO DETERMINE IF THE PROVEN TECHNIQUE OF ELECTROPHORETIC DESORPTION (ED) CAN BE USED TO EFFECTIVELY REGENERATE IMMUNOLOGICALLY ACTIVE SURFACES SUITABLE FOR USE WITH MICROELECTRONIC BIOSENSORS. PREVIOUS WORK ON ED WAS DONE WITH CHROMATOGRAPHIC GELS, NOT PLANAR SURFACES. A SYSTEM FOR ED OF PLANAR SENSOR SURFACES WILL BE DEVELOPED; THE SYSTEM WILL BE OPTIMIZED AND EVALUATED FOR THE EFFICIENCY OF REGENERATION AND THE REUSABILITY OF THE REGENERATED SURFACE. FACTORS TO BE CONSIDERED INCLUDE: ELECTRIC FIELD GEOMETRIES, POWER REQUIREMENTS, PH, IONIC STRENGTH, TIME REQUIREMENTS, EFFICIENCY OF ELUTION AND REUSABILITY OF THE REGENERATED SURFACE. THE COMBINATION OF THIS TECHNIQUE WILL CHAOTROPIC AGENTS AND SURFACTANTS WILL ALSO BE STUDIED. THE REMOVAL OF BOTH LARGE AND SMALL MOLECULES WILL BE STUDIED. THE MODEL SYSTEMS WILL BE BASED ON ICSC SAW SENSORS. IT IS EXPECTED THAT THE INFORMATION GAINED FROM THIS STUDY SHOULD BE APPLICABLE TO OTHER ELECTRONIC AND OPTICAL MICRO-SENSOR SYSTEMS AND RECEPTOR-BASED BIOSENSORS WHICH WILL BE STUDIED IN PHASE II OF THIS PROGRAM.

* information listed above is at the time of submission.

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