GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3294
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Integrated Genetics
31 New York Avenue, Framingham, MA, 01701
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Edward Bernstein
 Principal Investigator
 (617) 875-1336
Business Contact
Phone: () -
Research Institution
N/A
Abstract
HUNTINGTON'S DISEASE (HD) IS A PROGRESSIVE, NEURODEGENERATIVE, AUTOSOMAL DOMINANT DISEASE WHICH GENERALLY MANIFESTS ITSELF IN THE THIRD TO FIFTH DECADES OF LIFE. THE GOAL OF THIS PROJECT IS TO DEVELOP A GENETIC LINKAGE TEST FOR THE PRESYMPTOMATIC AND PRENATAL DIAGNOSIS OF HUNTINGTON'S DISEASE. IN PHASE I, WE WILL DEVELOP THE CAPABILITY FOR CONDUCTING A FIELD TRIAL IN PHASE II FOR THE TESTING OF INDIVIDUALS AT RISK FOR HUNTINGTON'S DISEASE BY GENETIC LINKAGE ANALYSIS. THE TECHNICAL FEASIBILITY OF IDENTIFYING PARTICULAR GENOTYPES ASSOCIATED WITH HD-LINKED POLYMORPHIC DNA MARKERS WILL BE RELIABLY AND ACCURATELY DETERMINED DURING PHASE I. PROCEDURES FOR SAMPLE COLLECTION, STORAGE, DNA EXTRACTION, AND HYBRIDIZATION WILL BE OPTIMIZED AND A PILOT REFERENCE LABORATORY FOR HAPLOTYPING WITH HD-LINKED MARKERS WILL BE ESTABLISHED. CRITICAL ELEMENTS ASSOCIATED WITH THE ADMINISTRATION OF A GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE WILL BE IDENTIFIED AND PROCEDURES

* information listed above is at the time of submission.

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