GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
3294
Agency Tracking Number:
3294
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
31 New York Avenue, Framingham, MA, 01701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Edward Bernstein
Principal Investigator
(617) 875-1336
Business Contact:
() -
Research Institution:
n/a
Abstract
HUNTINGTON'S DISEASE (HD) IS A PROGRESSIVE, NEURODEGENERATIVE, AUTOSOMAL DOMINANT DISEASE WHICH GENERALLY MANIFESTS ITSELF IN THE THIRD TO FIFTH DECADES OF LIFE. THE GOAL OF THIS PROJECT IS TO DEVELOP A GENETIC LINKAGE TEST FOR THE PRESYMPTOMATIC AND PRENATAL DIAGNOSIS OF HUNTINGTON'S DISEASE. IN PHASE I, WE WILL DEVELOP THE CAPABILITY FOR CONDUCTING A FIELD TRIAL IN PHASE II FOR THE TESTING OF INDIVIDUALS AT RISK FOR HUNTINGTON'S DISEASE BY GENETIC LINKAGE ANALYSIS. THE TECHNICAL FEASIBILITY OF IDENTIFYING PARTICULAR GENOTYPES ASSOCIATED WITH HD-LINKED POLYMORPHIC DNA MARKERS WILL BE RELIABLY AND ACCURATELY DETERMINED DURING PHASE I. PROCEDURES FOR SAMPLE COLLECTION, STORAGE, DNA EXTRACTION, AND HYBRIDIZATION WILL BE OPTIMIZED AND A PILOT REFERENCE LABORATORY FOR HAPLOTYPING WITH HD-LINKED MARKERS WILL BE ESTABLISHED. CRITICAL ELEMENTS ASSOCIATED WITH THE ADMINISTRATION OF A GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE WILL BE IDENTIFIED AND PROCEDURES

* information listed above is at the time of submission.

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