CHROMOSOME 1P ACCOUNTS FOR APPROXIMATELY 5% OF THE HUMAN GENOME.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3065
Amount: $49,124.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Integrated Genetics
31 New York Avenue, Framingham, MA, 01701
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 KATHERINE W. KLINGER
 PRINCIPAL INVESTIGATOR
 (617) 875-1336
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CHROMOSOME 1P ACCOUNTS FOR APPROXIMATELY 5% OF THE HUMAN GENOME. THE GENES FOR A NUMBER OF HUMAN DISEASES HAVE BEEN TENTATIVELY ASSIGNED TO THIS REGION. HOWEVER, FIRM ASSIGNMENT IS NOT POSSIBLE FOR MANY OF THESE DISEASES, INCLUDING HEREDITARY MALIGNANT MELANOMA. ACCURATE MAPPING OF THESE GENES REQUIRES THE IDENTIFICATION OF ADDITIONAL MARKERS. THE-STATE-OF-THE-ART APPROACH TO HUMAN GENE MAPPING IS TO IDENTIFY RANDOM SINGLE-COPY DNA PROBES THAT DETECT DNA SEQUENCE POLYMORPHISMS, AND TO ORDER THESE POLYMORPHIC LOCI BY LINKAGE ANALYSIS. DISEASE GENES OF INTEREST ARE THEN MAPPED BY LINKAGE TO THE MARKER LOCI. THE GOAL OF THIS PROJECT IS TO USE RECOMBINANT DNA TECHNOLOGY TO DEVELOP A LIBRARY OF CHROMOSOME 1P RESTRICTION FRAGMENT LENGTH POLYMORPHISMS (RFLPS). IN PHASE I A SMALL NUMBER OF RFLPS LINKED TO THE RH LOCUS WILL BE IDENTIFIED. IN PHASE II THE

* information listed above is at the time of submission.

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