TRANSGENIC MICE PROVIDE APPROPRIATE MODEL SYSTEMS TO STUDY THE GENESIS, MAINTENANCE, AND TRANSMISSION OF PARTICULAR TYPES OF NEOPLASMS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4800
Agency Tracking Number:
4800
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
31 New York Avenue, Framingham, MA, 01701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KATHERINE GORDON
PRINCIPAL INVESTIGATOR
(617) 875-1336
Business Contact:
() -
Research Institute:
n/a
Abstract
TRANSGENIC MICE PROVIDE APPROPRIATE MODEL SYSTEMS TO STUDY THE GENESIS, MAINTENANCE, AND TRANSMISSION OF PARTICULAR TYPES OF NEOPLASMS. IN ADDITION, IMMORTALIZED SOMATIC CELLSCAN BE CULTURED FROM TRANSGENIC MICE IN WHICH SV-40 EARLY REGION DNA WAS INTRODUCED INTO EMBRYOS AND WAS TARGETED IN THE RESULTANT MICE WITH APPROPRIATE PROMOTERS. RESEARCHERS WILL USE THIS SYSTEM TO GENERATE MICE FROM WHICH IMMORTALIZED CELL LINES CAN BE ESTABLISHED AND STUDIED FOR OPTIMAL EXPRESSION OF THERAPEUTIC PROTEINS. IN PHASE I, INTEGRATED GENETICS WILL SET UP THE TRANSGENIC MOUSE SYSTEM USING MODEL VECTORS THAT HAVE BEEN SHOWN TO GIVE RISE TO TRANSGENIC ANIMALS AT HIGH FREQUENCIES. THE FOCUS OF THE CURRENT PROPOSAL IS TO SET UP THE MICROINJECTION TECHNOLOGY AND SUPPORT PROCEDURES TO MAINTAIN THE MICE AND ANALYZE DATA.

* information listed above is at the time of submission.

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