ERYTHROPOIETIN IS AN IMPORTANT HORMONE THAT REGULATES THE PRODUCTION OF RED BLOOD CELLS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
5015
Agency Tracking Number:
5015
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
31 New York Avenue, Framingham, MA, 01701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
RICHARD H DOUGLAS
PRINCIPAL INVESTIGATOR
(617) 875-1336
Business Contact:
() -
Research Institute:
n/a
Abstract
ERYTHROPOIETIN IS AN IMPORTANT HORMONE THAT REGULATES THE PRODUCTION OF RED BLOOD CELLS. IT IS PRODUCED IN THE KIDNEYIN RESPONSE TO HYPOXIA. SEVERAL ANEMIAS AND CYTHEMIAS ARE ASSOCIATED WITH ABNORMAL LEVELS OF ERYTHROPOIETIN. THE GOALOF THIS PROJECT IS TO DEVELOP A HIGHLY SENSITIVE AND ACCURATE ERYTHROPOIETIN ASSAY FOR USE IN ERYTHROPOIETIN RESEARCH AND FOR THE DIAGNOSIS OF DISEASES. SUCH AN ASSAY IS CURRENTLY NOT AVAILABLE COMMERCIALLY. IN PHASE I, MONOCLONAL AND POLYCLONAL ANTIBODIES WILL BE PRODUCED AGAINST TWO DIFFERENT SYNTHETIC ERYTHROPOIETIN PEPTIDES. ONE PEPTIDE CONSISTS OF AN INTERNAL HYDROPHILIC REGION OF THE ERYTHROPOIETIN MOLECULE, AND THE OTHER PEPTIDE INCLUDES THE CARBOXY TERMINAL AMINO ACIDS. THESE ANTIBODIES WILL BE TESTED FOR THEIR SUITABILITY FOR USE IN DIAGNOSTIC TESTS. THE PRODUCTION OF HIGHLY SPECIFIC ANTIBODIES AGAINST TWO POTENTIALLY DIFFERENT ERYTHROPOIETIN EPITOPES IN PHASE I WILL GREATLY FACILITATE THE DESIGN OF A NOVEL, EASY FORMAT FOR A HIGHLY ACCURATE AND SENSITIVE NONRADIOACTIVE ERYTHROPOIETIN IMMUNOASSAY IN PHASE II.

* information listed above is at the time of submission.

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