THE LONG-TERM OBJECTIVE OF THE RESEARCH DESCRIBED IN THIS APPLICATION IS TO DEVELOP A UNIQUE TECHNOLOGY FOR THE TRANS-FER OF CLONED GENES INTO THE BOVINE GERM LINE.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4841
Agency Tracking Number:
4841
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
31 New York Avenue, Framingham, MA, 01701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KATHERINE GORDON
PRINCIPAL INVESTIGATOR
(617) 875-1336
Business Contact:
() -
Research Institute:
n/a
Abstract
THE LONG-TERM OBJECTIVE OF THE RESEARCH DESCRIBED IN THIS APPLICATION IS TO DEVELOP A UNIQUE TECHNOLOGY FOR THE TRANS-FER OF CLONED GENES INTO THE BOVINE GERM LINE. IN THE LONG TERM, SELECTION OF GENES TO BE INTRODUCED WILL BE AIMED AT PROMOTING ANIMAL LONGEVITY, DISEASE RESISTANCE, ACCELERATED GROWTH PARAMETERS, AND INCREASED NUTRIENT UTILIZATION. EXISTING TECHNOLOGIES FOR THE TRANSFER OF CLONED GENES INTO OTHER TYPES ON EMBRYOS UTILIZE NUCLEAR MICROINJECTION, BUT THAT APPROACH MAY BE UNACCEPTABLE FOR THE EMBRYOS OF AGRI- CULTURAL ANIMALS DUE TO TECHNICAL PROBLEMS. INSTEAD, WE PROPOSE TO DEVELOP RETROVIRAL VECTORS FOR THE INFECTION OF BOVINE EMBRYOS, A TECHNIQUE THAT WILL OBVIATE THE NEED FOR INJECTION. THE SPECIFIC AIMS OF THIS PHASE I RESEARCH PROPOSAL ARE: (1) TO CONSTRUCT SUCH VECTORS CONTAINING A MODEL GENE FOR FEASIBILITY STUDIES; AND (2) TO TEST THE INFECTIVITY AND SPECIES SPECIFICITY OF SUCH VECTORS IN A TISSUE CULTURE MODEL SYSTEM.

* information listed above is at the time of submission.

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