INTERPHASE CYTOGENETICS: CHROMOSOME SPECIFIC DNA PROBES

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$462,176.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
8027
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Integrated Genetics Inc.
1 Mountain Rd, Framingham, MA, 01701
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CURRENT TECHNIQUES FOR THE DETECTION OF CHROMOSOME ANOMALIESARE TIME CONSUMING AND REQUIRE CELL CULTURE AND THE PREPARATION OF METAPHASE CHROMOSOMES. INTERPHASE CYTOGENETICS USING IN SITU HYBRIDIZATION OF FLUORESCENT LABELED DNA PROBES IS POTENTIALLY RAPID, RELATIVELY INEXPENSIVE, AND LENDS ITSELF TO AUTOMATION. IT IS THE GOALOF THIS RESEARCH TO GENERATE CHROMOSOME-SPECIFIC DNA PROBES SUITABLE FOR DETECTION OF CHROMOSOMAL ANOMALIES INCLUDING NUMERICAL VARIATIONS, TRANSLOCATIONS AND DELETIONS. THE SPECIFIC AIMS OF THIS PROPOSAL ARE (1) TO SELECT A SUBSET OFCLONES DERIVED FROM CHROMOSOME 7 HTF ISLANDS LOCALIZED TO VARIOUS REGIONS OF CHROMOSOME 7 AND (2) TO EVALUATE THESE CLONES FOR THE ABILITY TO DECORATE METAPHASE AND INTERPHASE CHROMOSOMES.

* information listed above is at the time of submission.

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