ASSAY

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4911
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Po Box 13501, Rsch Triangle Park, NC, 27709
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 T.K. RAO
 PRINCIPAL INVESTIGATOR
 (919) 544-4589
Business Contact
Phone: () -
Research Institution
N/A
Abstract
PHASE I RESEARCH WILL EXAMINE THE RELATIONSHIP BETWEEN CYTOTOXICITY, MUTAGENICITY, AND CLASTOGENICITY BY USING A NUMBER OF BIOCHEMICAL TECHNIQUES: DNA ADDUCT FORMATION, DNA/DNA AND DNA/PROTEIN CROSS-LINKING, DNA STRAND BREAKS, AND SEQUENCE ANALYSIS OF DNA. A SELECT GROUP OF CHEMICAL AGENTS WILL BE EVALUATED FOR MUTAGENIC ACTIVITY IN THE MOUSELYMPHOMA (L5178Y/TK+/-) ASSAY SYSTEM BY SELECTING FOR TRIFLUOROTHYMIDINE (TFT) RESISTANCE. SMALL AND LARGE COLONYINDUCTION WILL BE CORRELATED TO CHEMICALLY INDUCED CHROMOSO-MAL ABERRATIONS AND KARYOTYPE ANALYSIS. DNA SEQUENCE ANALYSIS WILL BE PERFORMED WITH BOTH LARGE AND SMALL TK-/- MUTANT COLONIES.

* Information listed above is at the time of submission. *

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