ASSAY

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Award Information

Agency:

Department of Health and Human Services

Branch:

N/A

Amount:

$50,000.00

Award Year:

1986

Program:

SBIR

Phase:

Phase I

Contract:

N/A

Agency Tracking Number:

4911

Solicitation Year:

N/A

Solicitation Topic Code:

N/A

Solicitation Number:

N/A

Small Business Information

Integrated Laboratory Systems

Po Box 13501, Rsch Triangle Park, NC, 27709

Hubzone Owned:

Socially and Economically Disadvantaged:

Woman Owned:

Duns:

N/A

Principal Investigator

Name: T.K. RAO
Title: PRINCIPAL INVESTIGATOR
Phone: (919) 544-4589

Business Contact

Phone: () -

Research Institution

N/A

Abstract

PHASE I RESEARCH WILL EXAMINE THE RELATIONSHIP BETWEEN CYTOTOXICITY, MUTAGENICITY, AND CLASTOGENICITY BY USING A NUMBER OF BIOCHEMICAL TECHNIQUES: DNA ADDUCT FORMATION, DNA/DNA AND DNA/PROTEIN CROSS-LINKING, DNA STRAND BREAKS, AND SEQUENCE ANALYSIS OF DNA. A SELECT GROUP OF CHEMICAL AGENTS WILL BE EVALUATED FOR MUTAGENIC ACTIVITY IN THE MOUSELYMPHOMA (L5178Y/TK+/-) ASSAY SYSTEM BY SELECTING FOR TRIFLUOROTHYMIDINE (TFT) RESISTANCE. SMALL AND LARGE COLONYINDUCTION WILL BE CORRELATED TO CHEMICALLY INDUCED CHROMOSO-MAL ABERRATIONS AND KARYOTYPE ANALYSIS. DNA SEQUENCE ANALYSIS WILL BE PERFORMED WITH BOTH LARGE AND SMALL TK-/- MUTANT COLONIES.

* information listed above is at the time of submission.

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