Transplacental Detection of Mutagenesis

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$96,797.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 HD33637-01,
Award Id:
29303
Agency Tracking Number:
29303
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
800-12 Capitola Drive/Alston T, Durham, NC, 27713
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Barbara Shane
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
Exposure of animals and man during development can result in teratogenic, mutagenic, and carcinogenThis research will determine whether transgenic mouse models used for mutagenicity testing can be ustransplacental mutagens. Phase I will be a proof-of-principle study to demonstrate the applicabilityknown mutagen. In Phase II, the assay will be further characterized using additional chemicals and dprotocols, as well as by determining whether or not the mutant spectra of the mutagen of interest istissue of the mother and her offspring. This assay will be used to identify transplacental mutagensopportunity of determining whether mutations which occur during development are related to teratogenoutcomes.

* information listed above is at the time of submission.

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