THERE ARE NO SENSITIVE METHODS FOR THE DIAGNOSIS OF METASTASES AND LYMPH NODE INVOLVEMENT IN HUMAN SQUAMOUS CELL CARCINOMA (SCC) OF THE HEAD AND NECK REGION.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
2988
Agency Tracking Number:
2988
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Intek Diagnostics, Inc. Forme (Currently Intek Diagnostics Inc.)
1450 Rollins Road, Burlingame, CA, 94010
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
TOBY GOTTFRIED
PRINCIPAL INVESTIGATOR
(415) 340-0530
Business Contact:
() -
Research Institution:
n/a
Abstract
THERE ARE NO SENSITIVE METHODS FOR THE DIAGNOSIS OF METASTASES AND LYMPH NODE INVOLVEMENT IN HUMAN SQUAMOUS CELL CARCINOMA (SCC) OF THE HEAD AND NECK REGION. RADIOIMMUNODETECTION IS CAPABLE OF HIGH RESOLUTION AND SENSITIVITY IN LOCATING TUMORS. THE LONG-TERM GOAL OF THIS RESEARCH PROPOSAL IS THE DEVELOPMENT OF RADIOPHARMACEUTICALS FOR RADIOIMMUNODETECTION IN PATIENTS WITH SCC OF THE HEAD AND NECK. THE SPECIFIC AIM OF THIS PROPOSAL IS TO EVALUATE 20 HIGHLY SCC TUMOR-ASSOCIATED AND POSSIBLY TUMOR-SPECIFIC MONOCLONAL ANTIBODIES PRODUCED AT INTEK FOR USE IN RADIOIMMUNODETECTION. SUCCESSFUL COMPLETION OF PHASE I INCLUDES: 1.A RELEVANT NUDE MOUSE MODEL WHICH WILL HOST HISTOLOGICALLY EQUIVALENT HUMAN XENOGRAFTS (175MM IN DIAMETER) IN THE HEAD AND NECK REGION FOR THE ONGOING EVALUATION OF SCC MONOCLONAL ANTIBODIES; 2.SELECTION OF SCC MONOCLONAL ANTIBODIES AND RADIOLABELING PROCEDURES THAT LEAD TO IMAGING OF TUMORS WITH HIGH SENSITIVITY IN THE NUDE MOUSE MODEL; 3.IMPROVED IMAGING CAPABILITY WITH COMBINATIONS OF MONOCLONAL ANTIBODIES. THOSE MONOCLONAL ANTIBODIES SELECTED IN PHASE I AS POTENTIAL RADIOPHARMACEUTICALS FOR IMAGING SCC WILL BE EVALUATED IN A LARGE-SCALE CLINICAL STUDY IN PHASE II. DEMONSTRATION OF DIAGNOSTIC CAPABILITY WILL REALIZE THE INTRODUCTION OF RADIOIMMUNODETECTION IN SCC.

* information listed above is at the time of submission.

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