Optical Fiber Microsensors for Monitoring Protein Crystal Growth

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$69,996.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
NAS8-01164
Agency Tracking Number:
012962
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Intelligent Optical Systems, Inc.
2520 W. 237th Street, Torrance, CA, 90505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Claudio Egalon
Principal Investigator
(310) 530-7130
CEgalon@intopsys.com
Business Contact:
Robert Lieberman
Sr. Vice President & CTO
(310) 530-7130
RLieberman@intopsys.com
Research Institution:
n/a
Abstract
Intelligent Optical Systems (IOS), in collaboration with Dr. Alex McPherson and Dr. Stanley Koszelak of the University of California, Irvine, proposes to develop a family of unique sub-micron optical fiber sensors to monitor pH, temperature, and ionic strength during protein crystal growth. The proposed device combines an array of sub-micron tapered optical fibers with near?field optical (NFO) techniques and polymer-immobilized fluorescent indicators. The result is a versatile, self?referenced, multi-analyte, high-speed sensor that will be used to constantly monitor the parameters of a protein crystal growth (PCG) chamber during protein crystallization. Since small differences in pH, temperature, and ionic strength may affect the quality of the resulting crystals, it is highly desirable to monitor the solution parameters. However, because spaceborne crystal growth chambers are very small (on the order of tens of microliters), the measurement of these parameters requires the use of microscopic and sub-microscopic instrumentation that is not currently available. IOS proposes to develop a system capable of determining the influence of crystallization parameters on the size, quality, and growth rate of protein crystals in extremely small volumes. The resulting instrument will be compact enough to be used aboard space platforms, and will lead to a commercial product with medical and pharmaceutical applications.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government