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HIGH-DENSITY DIGITAL MICROSPOTTING ARRAYS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 1R43CA090100-01
Amount: $99,997.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2520 W 237TH ST
TORRANCE, CA 90505
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 SRIVATSA VENKATASUBBARAO
 () -
Business Contact
Phone: (310) 530-7130
Email: ASHARMA@INTOPSYS.COM
Research Institution
N/A
Abstract

APPLICANT'S DESCRIPTION: The progression of cancer and the experimental
reversal of tumorigenicity are accompanied by complex changes in the patterns
of gene expression. DNA micro-arrays make it possible to quickly generate large
amounts of data for gene expression monitoring, target screening, and many
other applications. Understanding the function of individual genes is a
challenging objective. Bioanalytical microsystems, such as immunologic and
hybridization assays in micro-array format, require using high-density spotting
technology that can dispense tiny (nanoliter or picoliter) quantities of
solutions containing sufficient biospecific probes onto a given solid support.
To achieve this objective, Intelligent Optical Systems (lOS) will develop
microspotting arrays that offer millions of features with consistent spot size
and spot-to-spot reproducibility, and will enable the rapid mass production of
DNA chips. The proposed spotting arrays are extremely versatile. In Phase I,
lOS will investigate the feasibility of MEMS-based spotting arrays by testing
DNA samples and evaluating the consistency of spotted sample sizes, quantities,
spot uniformity, spot density, deposition precision, minimal spot size, and the
coefficient of spot-to-spot variation.
PROPOSED COMMERCIAL APPLICATION:
MEMS-based spotting devices will be used in the fabrication of DNA chips in many industries,
such as health care and agriculture, and for food and water testing, and forensic and paternity
testing. The commercial potential of this technology is very large, since it will revolutionize the
fabrication of biochips, and will find use in environments ranging from clinical laboratories to
biotechnology research facilities.

* Information listed above is at the time of submission. *

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