Optical Sensor for LDL and HDL Cholesterol Determination

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,996.00
Award Year:
2001
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
54009
Agency Tracking Number:
1R43HL065910-01A1
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2520 W 237TH ST, TORRANCE, CA, 90505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
SRIVATSAVENKATASUBBARAO
() -
Business Contact:
(310) 530-7130
RLIEBERMAN@INTOPSYS.COM
Research Institute:
n/a
Abstract
The association between elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased risk of premature coronary heart disease is well established. Further, an increase in the level of LDL-C with normal levels of cholesterol can result in an increased risk for coronary heart disease. On the other hand, high-density lipoprotein cholesterol (HDL-C) is often observed to have a protective effect. The instant cholesterol measurement kits currently on the market can only measure the total cholesterol content. They cannot quantify the low-density lipoprotein cholesterol (LDL-C) and high-density liprotein cholesterol (HDL-C) separately. Intelligent Optical Systems (IOS), in collaboration with Dr. Karol E. Watson, Co-Director of the Cholesterol and Lipid Management Center at the Unversity of California, Los Angeles. seeks to design and construct a low-cost, single-step. self-calibrated cholesterol sensor for the simultaneous, quantitative determination of LDL-C and HDL-C from fresh human serum. The proposed sensor is internally calibrated to account for any errors in the measurement. The innovative optical design and assay format ensures that the cost of the optical reader will be about $100 and each test will cost about $2.00. The calibration procedures used in this assay will make this sensor immune to matrix effects, and serum samples can be directly tested.

* information listed above is at the time of submission.

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