Portable Gene Expression Array Reader for NASA Applications

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$69,995.00
Award Year:
2003
Program:
SBIR
Phase:
Phase I
Contract:
NAS8-03016
Award Id:
63255
Agency Tracking Number:
023960
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2520 W. 237th Street, Torrance, CA, 90505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
SrivVenkatasubbarao
(310) 530-7130
sbirproposals@intopsys.com
Business Contact:
AshutoshSharma
Business Official
(310) 530-7130
r&doffice@intopsys.com
Research Institute:
n/a
Abstract
In the last few decades our understanding of life has expanded considerably with major progress in the fields of biotechnology, molecular biology, and genetics. This has culminated in deciphering the human genome. Microarray technologies have now made it possible to identify and study the expression of thousands of genes simultaneously. Currently used microarray readers are predominantly fluorescence readers for their superior sensitivity. Alternative readers that are simpler, less expensive, compact, and portable are desired for space applications and various in situ applications. Intelligent Optical Systems proposes to develop a highly sensitive, lightweight, compact, microarray reader for gene expression analysis. This proposal explores the utilization of ellipsometry in conjunction with nanoparticle-based amplification for creating an imaging microarray reader. The feasibility of the principle will be demonstrated in Phase I with commercially available oligonucleotide microarrays. The sensitivity, spatial resolution, the ease-of-use of the reader will be tested and validated to fluorescence microarray based measurements.

* information listed above is at the time of submission.

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