Portable Gene Expression Array Reader for NASA Applications

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$596,494.00
Award Year:
2004
Program:
SBIR
Phase:
Phase II
Contract:
NNM04AA24C
Award Id:
63255
Agency Tracking Number:
023960
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2520 W. 237th Street, Torrance, CA, 90505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
033449757
Principal Investigator:
Srivatsa Venkatasubbarao
Principal Investigator
(310) 530-7130
sbirproposals@intopsys.com
Business Contact:
Ashutos Sharma
Chief R&D Officer
(310) 530-7130
sbirproposals@intopsys.com
Research Institute:
n/a
Abstract
In recent decades, there has been significant progress in the fields of biotechnology, molecular biology, and genetics. These efforts have enabled deciphering of the human genome, and have fueled the development of microarray technologies for studying the very basis of life; how genes and proteins develop, function, and how they can change under certain conditions. Commercially available microarray readers are not suitable for space use. To perform experiments in space, NASA needs a portable, lightweight, sensitive microarray reader. In Phase I, Intelligent Optical Systems (IOS) demonstrated a lightweight, low power, compact, gene microarray reader for monitoring gene expression. The high sensitivity was achieved by utilizing nanoparticles as labels, and evanescent field ellipsometry for detection. The Phase I results showed an attractive alternative to fluorescence as a microarray readout method. The sensitivity, resolution, measurement speed, and simplicity of IOS?s system exactly match NASA's requirements. In Phase II, IOS will design and construct a compact portable microarray reader for NASA?s use. The biochip preparation and testing procedures will be optimized and the prototype device?s performance will be optimized. At the end of Phase II, IOS will deliver to NASA an effective, working prototype device, along with 20 gene chips for testing.

* information listed above is at the time of submission.

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