Optical Nutrients Monitor for Bioreactor Applications in Zero Gravity

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NAS2-03121
Agency Tracking Number: 023947
Amount: $69,998.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Intelligent Optical Systems, Inc.
2520 W. 237th Street, Torrance, CA, 90505
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Raghuvir Singh
 Principal Investigator
 (310) 530-7130
Business Contact
 Ashutosh Sharma
Title: Business Official
Phone: (310) 530-7130
Email: r&doffice@intopsys.com
Research Institution
Intelligent Optical Systems, Inc. proposes to develop a fluorescence detection based miniature multisensor probe and detection system to monitor cell nutrient parameters in zero gravity. The proposed sensor system can be integrated into NASA?s bioreactor hardware to enhance performance. Luminescent nano-particles will be used as fluorescent indicators to provide greater signal intensity and to reduce photo-degradation. The ultimate optical nutrients monitor will be capable of detecting and monitoring vital nutrient parameters such as pH, temperature, dissolved carbon dioxide, dissolved oxygen, and glucose. The device will provide a continuous, unmanned measurement of the bioreactor?s parameters. The optical monitor will require no reagent replacement and is projected to be capable of long term unattended real-time monitoring of cell culture media.In Phase I, we will demonstrate the feasibility and sensitivity of the optical monitoring device and the single source fluorescence system using buffers and cell culture media (lacto bacillus). In Phase II, we will construct and test a field deployable prototype monitor to be used in a NASA bioreactor project.

* information listed above is at the time of submission.

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