A Field-Usable Portable Multiplexed Device for Biomarker Detection in Body Fluids

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-06-M-6698
Agency Tracking Number: F061-035-1133
Amount: $99,949.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: AF06-035
Solicitation Number: 2006.1
Small Business Information
2520 W. 237th Street, Torrance, CA, 90505
DUNS: 033449757
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Srivatsa Venkatasubbarao
 Senior Scientist
 (310) 530-7130
Business Contact
 Lothar Kempen
Title: Vice President, R&D
Phone: (310) 530-7130
Email: lkempen@intopsys.com
Research Institution
This proposal describes the development of a portable, handheld, battery-operable optical reader to simultaneously identify multiple DNA and protein biomarkers in biological fluids for field use. The proposed device will not require fluorescent or chemiluminescent or other labels. Instead, the proposed optical method will produce a new imaging ellipsometer to offer the high sensitivity and multiplex capability of a laboratory grade instrument in a portable, field-deployable device. The sensing chip consists of immobilized biomolecules (DNA, antibodies or other recognition elements) and is connected to the sample application region by microfluidics channels that transport the biomarker containing samples to the sensing area. In Phase I of this project we will construct the device and fabricate sensing chips for biomarker testing. A software program will be written to read the results from the measurements on the device. Methods to stabilize DNA and proteins on the sensor chips for extended field use will also be explored. The sensing chips will be tested and results will be validated to current standards. The results can be extended in Phase II and beyond for biomarkers of specific interest.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government