Conjunctival Continuous Blood and Tissue Gas Monitor for Infant Care

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$146,512.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43EY017482-01A1
Award Id:
85647
Agency Tracking Number:
EY017482
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
INTELLIGENT OPTICAL SYSTEMS, INC., 2520 W 237TH ST, TORRANCE, CA, 90505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
033449757
Principal Investigator:
LOTHARKEMPEN
() -
Business Contact:
SANDYHONDA
() -
shonda@intopsys.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The monitoring of blood gases is often essential in evaluating patients in surgery, critical care or in emergency rooms. Measuring arterial or venous values involves either puncture of a vessel and blood removal for int ermittent testing, or the insertion of an intravascular sensor. For newborns in critical care, and particularly the premature infant requiring supplemental oxygen, blood and tissue gas levels are crucial. If the oxygen is insufficient, the infant may devel op cerebral palsy or expire, while too much oxygen may cause blindness from retinopathy. The patient's carbon dioxide level is important to indicate pulmonary and metabolic status, as is the pH value. The removal of blood for testing, however, represents a considerable risk for the fragile infant, and does not measure the perfusion of vital organs such as the brain. To solve this problem, Intelligent Optical Systems (IOS), in collaboration with the Los Angeles Biomedical Institute at Harbor-UCLA Medical Cen ter, proposes to develop a minimally invasive, continuous blood and tissue gas monitoring system for infants and critical care patients. The setup will be based on a thin, flexible, non-irritant fiberoptic probe placed on the conjunctiva of the patient's e ye. Four optical sensors embedded in the probe will determine the pH, carbon dioxide, and oxygen tension of the gas diffusing through the conjunctiva, together with the temperature. An electrooptic readout unit will interrogate the fiberoptic system, and c ontinuously display and monitor the patient's conjunctival or blood gases. Based on IOS' distributed fiber sensor technology, the system will be insensitive to the patient's head or ocular movements. Preliminary studies performed by our collaborators have validated this innovative detection approach. The proposed system fills an important gap in critical care for infants, making continuous blood and tissue gas monitoring available to fragile premature infants and newborns in intensive care, as well as for c ritically ill children and adults requiring intensive care or undergoing major surgery. Given both the minimal invasive nature of conjunctival monitoring and the importance of blood gas analysis, this system could become a standard tool in critical care, d uring surgery, and in the emergency room.

* information listed above is at the time of submission.

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