Field Portable Device for Brain Injury Diagnosis

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$729,997.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-07-C-0031
Award Id:
77503
Agency Tracking Number:
A062-153-0297
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2520 W. 237th Street, Torrance, CA, 90505
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
033449757
Principal Investigator:
SrivatsaVenkatasubbarao
Senior Scientist
(310) 530-7130
sbirproposals@intopsys.com
Business Contact:
LotharKempen
Vice President, R&D
(310) 530-7130
randdoffice@intopsys.com
Research Institute:
n/a
Abstract
Traumatic Brain Injury (TBI) is a major cause of cognitive deficits, as well as a series of physiological and psychological disorders, that can result in both short-term and long-term problems. Unfortunately, closed head injuries are difficult to detect, and early detection is necessary to improve the treatment and therapy of injured personnel. To address this important and urgent health problem, Intelligent Optical Systems, in collaboration with Prof. Edward Dixon of the University of Pittsburgh, proposes to develop a field test kit to diagnose TBI. Lateral flow assay test strips were designed and developed to measure the concentrations of S100fO and NSE. Phase I results show that the concentrations of the biomarkers S100fO and NSE correlate negatively with the Glasgow Coma Scale and the Glasgow Outcome Scale. This new assay format provides an easy-to-use format suitable for field-use. In Phase II, we will include additional biomarkers, optimize the test strips fabrication, develop a portable reader, and conduct clinical studies to characterize and validate the test strip performance. The successful completion of this project will result in a device that can be used by military personnel to rapidly diagnose TBI, even in battlefield conditions.

* information listed above is at the time of submission.

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