A Portable Field-Usable Multiplexed Device for Biomarker Detection in Body Fluids

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$749,993.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
FA8650-07-C-6757
Agency Tracking Number:
F061-035-1133
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
INTELLIGENT OPTICAL SYSTEMS, INC.
2520 W. 237th Street, Torrance, CA, 90505
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
033449757
Principal Investigator:
Srivatsa Venkatasubbarao
Senior Scientist
(310) 530-7130
sbirproposals@intopsys.com
Business Contact:
Lothar Kempen
Vice President, R&D
(310) 530-7130
randdoffice@intopsys.com
Research Institution:
n/a
Abstract
Recent advances in genomics and proteomics have provided a number of promising biomarkers that could be used to indicate the onset of a disease, the progression of treatment, and exposure to biological and chemical agents. In Phase I, Intelligent Optical Systems (IOS) developed a novel optical detection concept and constructed a benchtop prototype that can simultaneously detect multiple protein and DNA markers from serum samples. This approach does not require labels and has sensitivity equivalent to fluorescence-based detection (a labeled approach). We also developed a multilayered soft lithography-based microfluidic flow cell that allows the precise transfer of nanoliter volumes of samples to the sensor array. In Phase II, we propose to miniaturize the Phase I benchtop prototype to develop a handheld reader. The optics, microfluidics, and sensor chip will be integrated into a battery-operated, easy-to-use, DNA and protein biomarker detection unit for use by military personnel. The proposed device represents the utilization of advances in life sciences, microfabrication techniques, and consumer-electronics to provide an important tool for medical diagnostics and sensing applications. The integration of these state-of-the-art technologies will provide IOS with the ability to develop economically viable, field-usable, versatile diagnostic platforms for DNA and protein detection.

* information listed above is at the time of submission.

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