A Portable Field-Usable Multiplexed Device for Biomarker Detection in Body Fluids

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-07-C-6757
Agency Tracking Number: F061-035-1133
Amount: $749,993.00
Phase: Phase II
Program: SBIR
Awards Year: 2007
Solicitation Year: 2006
Solicitation Topic Code: AF06-035
Solicitation Number: 2006.1
Small Business Information
INTELLIGENT OPTICAL SYSTEMS, INC.
2520 W. 237th Street, Torrance, CA, 90505
DUNS: 033449757
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Srivatsa Venkatasubbarao
 Senior Scientist
 (310) 530-7130
 sbirproposals@intopsys.com
Business Contact
 Lothar Kempen
Title: Vice President, R&D
Phone: (310) 530-7130
Email: randdoffice@intopsys.com
Research Institution
N/A
Abstract
Recent advances in genomics and proteomics have provided a number of promising biomarkers that could be used to indicate the onset of a disease, the progression of treatment, and exposure to biological and chemical agents. In Phase I, Intelligent Optical Systems (IOS) developed a novel optical detection concept and constructed a benchtop prototype that can simultaneously detect multiple protein and DNA markers from serum samples. This approach does not require labels and has sensitivity equivalent to fluorescence-based detection (a labeled approach). We also developed a multilayered soft lithography-based microfluidic flow cell that allows the precise transfer of nanoliter volumes of samples to the sensor array. In Phase II, we propose to miniaturize the Phase I benchtop prototype to develop a handheld reader. The optics, microfluidics, and sensor chip will be integrated into a battery-operated, easy-to-use, DNA and protein biomarker detection unit for use by military personnel. The proposed device represents the utilization of advances in life sciences, microfabrication techniques, and consumer-electronics to provide an important tool for medical diagnostics and sensing applications. The integration of these state-of-the-art technologies will provide IOS with the ability to develop economically viable, field-usable, versatile diagnostic platforms for DNA and protein detection.

* information listed above is at the time of submission.

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government