A Portable Field-Usable Multiplexed Device for Biomarker Detection in Body Fluids

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-07-C-6757
Agency Tracking Number: F061-035-1133
Amount: $749,993.00
Phase: Phase II
Program: SBIR
Awards Year: 2007
Solicitation Year: 2006
Solicitation Topic Code: AF06-035
Solicitation Number: 2006.1
Small Business Information
2520 W. 237th Street, Torrance, CA, 90505
DUNS: 033449757
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Srivatsa Venkatasubbarao
 Senior Scientist
 (310) 530-7130
Business Contact
 Lothar Kempen
Title: Vice President, R&D
Phone: (310) 530-7130
Email: randdoffice@intopsys.com
Research Institution
Recent advances in genomics and proteomics have provided a number of promising biomarkers that could be used to indicate the onset of a disease, the progression of treatment, and exposure to biological and chemical agents. In Phase I, Intelligent Optical Systems (IOS) developed a novel optical detection concept and constructed a benchtop prototype that can simultaneously detect multiple protein and DNA markers from serum samples. This approach does not require labels and has sensitivity equivalent to fluorescence-based detection (a labeled approach). We also developed a multilayered soft lithography-based microfluidic flow cell that allows the precise transfer of nanoliter volumes of samples to the sensor array. In Phase II, we propose to miniaturize the Phase I benchtop prototype to develop a handheld reader. The optics, microfluidics, and sensor chip will be integrated into a battery-operated, easy-to-use, DNA and protein biomarker detection unit for use by military personnel. The proposed device represents the utilization of advances in life sciences, microfabrication techniques, and consumer-electronics to provide an important tool for medical diagnostics and sensing applications. The integration of these state-of-the-art technologies will provide IOS with the ability to develop economically viable, field-usable, versatile diagnostic platforms for DNA and protein detection.

* information listed above is at the time of submission.

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