INSTRUMENTATION FOR DNA SEQUENCING

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19202
Amount: $49,947.00
Phase: Phase I
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
8150 Leesburg Pike, Vienna, VA, 22182
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Andrzej K Drukier
 (703) 790-8500
Business Contact
Phone: () -
Research Institution
N/A
Abstract
WE WILL DEVELOP A NOVEL TECHNIQUE FOR CONSIDERABLY INCREASING THE SPEED AND EFFICIENCY OF DNA SEQUENCING. THIS TECNIQUE IS BASED ON MULTIPLE ISOTOPIC DETERMINATION AND CAN BE EXTENDED TO ANALYSE THE OUTPUT OF OTHER FRACTIONATION PROCESSES, E.G. COLUMN CHROMATOGRAPHY. THE SYSTEM: (1) IS FULLY AUTOMATED, (2) PERMITS MULTI-ISOTOPE IMAGING, (3) PROVIDES SIZE AND SPATIAL RESOLUTION COMPARABLE TO NUCLEAR EMISSIONS, AND (4) AFFORDS QUANTUM DETECTION EFFICIENCY ORDER OF MAGNITUDE BETTER THAN "AUTORADIOGRAPHY". THE USE OF 15 ISOTOPES OF BROMINE/IODINE PROMISE ORDERS OF MAGNITUDE ACCELERATION OF ANALYTICAL PROCEDURES USED NOT ONLY IN DNA SEQUENCING, BUT ALSO IN HUNTING FOR GENES RESPONSIBLE FOR GENETIC DISEASE.

* Information listed above is at the time of submission. *

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