INSTRUMENTATION FOR DNA SEQUENCING

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,947.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19202
Agency Tracking Number:
19202
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
8150 Leesburg Pike, Vienna, VA, 22182
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Andrzej K Drukier
(703) 790-8500
Business Contact:
() -
Research Institute:
n/a
Abstract
WE WILL DEVELOP A NOVEL TECHNIQUE FOR CONSIDERABLY INCREASING THE SPEED AND EFFICIENCY OF DNA SEQUENCING. THIS TECNIQUE IS BASED ON MULTIPLE ISOTOPIC DETERMINATION AND CAN BE EXTENDED TO ANALYSE THE OUTPUT OF OTHER FRACTIONATION PROCESSES, E.G. COLUMN CHROMATOGRAPHY. THE SYSTEM: (1) IS FULLY AUTOMATED, (2) PERMITS MULTI-ISOTOPE IMAGING, (3) PROVIDES SIZE AND SPATIAL RESOLUTION COMPARABLE TO NUCLEAR EMISSIONS, AND (4) AFFORDS QUANTUM DETECTION EFFICIENCY ORDER OF MAGNITUDE BETTER THAN "AUTORADIOGRAPHY". THE USE OF 15 ISOTOPES OF BROMINE/IODINE PROMISE ORDERS OF MAGNITUDE ACCELERATION OF ANALYTICAL PROCEDURES USED NOT ONLY IN DNA SEQUENCING, BUT ALSO IN HUNTING FOR GENES RESPONSIBLE FOR GENETIC DISEASE.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government