Development of a phage-based technology for eliminating or significantly reducing contamination of fruits and vegetables with E. coli O157:H7

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$119,973.00
Award Year:
2006
Program:
SBIR
Phase:
Phase I
Contract:
W911QY-07-C-0009
Agency Tracking Number:
A062-178-1133
Solicitation Year:
2006
Solicitation Topic Code:
A06-178
Solicitation Number:
2006.2
Small Business Information
INTRALYTIX, INC.
The Columbus Center, 701 East Pratt Street, Baltimore, MD, 21202
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
005318758
Principal Investigator:
Alexander Sulakvelidze
Chief Scientist
(410) 625-2533
asulakvelidze@intralytix.com
Business Contact:
John Vazzana
President and CEO
(410) 625-2415
jvazzana@intralytix.com
Research Institution:
n/a
Abstract
Foodborne illnesses of microbial origin continue to be serious food safety problems worldwide, and they also may substantively hamper military operations. Thus, the availability of approaches which significantly reduce contamination of foods with various bacterial pathogens is of paramount importance for ensuring the safety and operational readiness of US troops worldwide, as well as for the safety of civilian populations. Ready-to-eat-foods (RTEFs) are of particular concern because they are not subjected to cooking, which kills most bacteria. However, bacterial decontamination of RTEFs presents considerable challenges because the efficacy of currently available chemical food-sanitizers is imperfect, and many of them damage food quality and adversely affect the environment. Thus, novel, environmentally-safe and effective approaches are needed to ensure the safety of foods that may be intentionally (e.g., bioterrorism) or naturally contaminated with pathogenic bacteria. Bacteriophages, viruses that kill bacteria, may provide one such approach. Intralytix is one of the world’s leading companies specializing in the development of phage preparations for improving food safety. Thus, in response to the US Army’s request to develop phage technology effective against biological pathogens in foods, we propose to develop and test a lytic phage preparation (“EcoPhage”) for reducing contamination of fruits and vegetables with E. coli O157:H7.

* information listed above is at the time of submission.

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