Development of a phage-based technology for eliminating or significantly reducing contamination of fruits, vegetables, and red meat with E. coli O157:

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911QY-07-C-0125
Agency Tracking Number: A062-178-1133
Amount: $1,328,270.00
Phase: Phase II
Program: SBIR
Awards Year: 2007
Solicitation Year: 2006
Solicitation Topic Code: A06-178
Solicitation Number: 2006.2
Small Business Information
The Columbus Center, 701 E. Pratt Street, Baltimore, MD, 21202
DUNS: 005318758
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Alexander Sulakvelidze
 Chief Scientist
 (410) 625-2533
Business Contact
 John Vazzana
Title: CEO
Phone: (410) 625-2415
Research Institution
The availability of approaches which reduce contamination of foods with bacterial pathogens is of paramount importance for ensuring the safety and operational readiness of US troops worldwide, as well as for the safety of civilian populations. Intralytix, Inc., has developed and is already commercializing a novel antibacterial technology that may become an important method for improving food safety. The technology utilizes bacteriophages, naturally-occurring predators of bacteria, to reduce the levels of their specifically-targeted pathogenic bacteria in a variety of food-processing settings. In response to the US Army’s request for applications (and our subsequently receiving a Phase I SBIR award) for the “development of novel, environmentally-friendly, non-chemical approaches for improving the safety of various food products,” we (i) developed a phage cocktail (ECP-100) possessing broad-spectrum lytic activity against E. coli 0157:H7, a virulent bacterium responsible for ca. 62,000 foodborne cases of disease/year in the US, and (ii) demonstrated that ECP-100 is effective in reducing contamination of various foods with E. coli 0157:H7. The present Phase II project is critical for supporting additional research required for optimizing ECP-100’s production, obtaining regulatory approvals, and subsequent commercialization.

* Information listed above is at the time of submission. *

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