Bacteriophage therapy for treating A. baumannii infected wounds

Award Information
Agency:
Department of Defense
Amount:
$99,991.00
Program:
STTR
Contract:
W81XWH-09-C-0164
Solitcitation Year:
2009
Solicitation Number:
2009.A
Branch:
Defense Advanced Research Projects Agency
Award Year:
2009
Phase:
Phase I
Agency Tracking Number:
A09A-026-0171
Solicitation Topic Code:
A09A-T026
Small Business Information
Intralytix, Inc.
The Columbus Center, 701 E. Pratt Street, Baltimore, MD, 21202
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
005318758
Principal Investigator
 Alexander Sulakvelidze
 Chief Scientist
 (410) 625-2533
 asulakvelidze@intralytix.com
Business Contact
 John Vazzana
Title: President and CEO
Phone: (410) 625-3813
Email: jvazzana@intralytix.com
Research Institution
 University of Florida
 Brian Prindle
 Division of Sponsored Research
P.O. Box 115500
Gainesville, FL, 32611 5500
 (352) 392-3516
 Nonprofit college or university
Abstract
Treatment of bacterial-infected wounds is one the most critical problems in modern medicine, and it presents one of the most significant challenges for US troops during combat operations. The management of bacteria in wounds is complicated by the existence of multidrug-resistant strains and mutants. Therefore, novel modalities for preventing and treating wound infections, one of which may be highly purified and characterized bacteriophage preparations, are required. Lytic phages (i.e., bacterial viruses that infect and lyse their specific bacterial hosts) have been used to treat bacterial infections since their discovery during the first decade of the 20th century. However, their therapeutic use gradually declined in the “Western World” after the advent of antibiotics. At the present time, there is renewed interest in phage-based prophylactic and therapeutic approaches because phages are active against multidrug-resistant, pathogenic bacterial strains and mutants. Our current application proposes to develop a potent lytic bacteriophage preparation/cocktail against A. baumannii – a major wound pathogen of particular concern to the US Army, and an increasingly important public health problem. In addition, we will develop two murine wound-infection models for future studies evaluating our A. baumannii phage cocktail’s efficacy in treating A. baumannii wound infections.

* information listed above is at the time of submission.

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