THE LONG TERM OBJECTIVE OF INTRON, INC.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,955.00
Award Year:
1984
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
1443
Agency Tracking Number:
1443
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
701 East Bay Street, Charleston, SC, 29403
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GREGORY B. WILSON
SENIOR VICE PRESIDENT
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE LONG TERM OBJECTIVE OF INTRON, INC. IS TO DEVELOP, MANUFACTURE AND MARKET A PROCUCT LINE OF ANTIGEN/ORGANISM SPECIFIC TRANSFER FACTORS (TF; AN IMMUNE POTENTIATOR) WITH APPLICATION FOR IMMUNOPROPHYLAXIS AND IMMUNOTHERAPY OF A WIDE VARIETY OF HUMAN VETERINARION DISEASES FOR WHICH A STRONG DEPENDENCY ON THE DEVELOPMENT CELL MEDIATED IMMUNITY HAS BEEN DOCUMENTED FOR HOST PROTECTION. TO ACCOMPLISH THIS OBJECTIVE, INTRON, INC. INTENDS TO DEVELOP ORGANISM/ANTIGEN SPECIFIC TRANSFER FACTORS BY IMMUNIZING PREGNANT DAIRY COWS. INTRON, INC. SCIENTISTS HAVE DEMONSTRATED THAT COWS WITH PRE-EXISTING CELLULAR IMMUNE RESPONSIVENESS TO CERTAIN MICROORGANISMS WILL HARBOR TF'S SPECIFIC FOR THESE ORGANISMS IN POST-PARTURITION COLOSTRUM (AND MILK). COLOSTRUM POTENTIALLY REPRESENTS AN INEXPENSIVE RICH SOURCE OF TF. IT IS NOT KNOWN, HOWEVER, WHEN OR BY WHAT ROUTE A COW MUST BE IMMUNIZED IN ORDER TO INDUCE THE ACCUMULATION OF A PARTICULAR ORGANISM SPECIFIC TF IN COLOSTRUM. PHASE I RESEARCH WILL ADDRESS: (A) THE IMMUNIZATION ROUTE TO BE USED, AND (B) THE NUMBER OF IMMUNIZATIONS AND THEIR TEMPORAL RELATIONSHIP TO PARTURITION. IN PHASE II, INTRON, INC. WILL EMPLOY THE INFORMATION OBTAINED FROM PHASE I TO BULK PRODUCE CERTAIN TF'S IN BOVINE'S FOR USE IN DOUBLE-BLIND CLINICAL TRIALS TO DOCUMENT THE EFFICIENCY OF THIS IMMUNE POTENTIATOR IN SELECTED HUMAN AND VETERINARIAN DISEASES WHICH HAVE A MAJOR SOCIO-ECONOMIC IMPACT.

* information listed above is at the time of submission.

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