You are here

RNA Detector-Molecule Methodology for Microorganism Biodetectors

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: N/A
Agency Tracking Number: 40394
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1998
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
Columbia Univ.bio Science, Park , 3960 Broadway Rm., New York, NY, 10032
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Abraham Grossman
 (212) 568-0365
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Current geopolitical strategies require effective warfare countermeasures to protect U.S. forces against biological and chemical threats. Today's molecular biology and immunological detection technologies cannot be used to produce automated biodetectors useable in the battlefield. New, improved detection technologies are needed to minimize the impact of chemical and biological weapons on Army personnel and provide a means to construct automated biodetectors that can identify a very few particles of any hazardous agent, regardless of interferant background. The final objective of the work proposed is to develop a highly sensitive RNA probe methodology to identify pathogenic bacteria and viruses. The methodology will underlay the foundation of RNA based tests that will be easy to perform as a simple enzymatic reaction at 37 degrees C under isothermal conditions in a single test tube format and can identify less than 100 target molecules in a specimen. Because of its extreme simplicity, the test could ultimately be incorporated into a small, portable, personal deviceuseable in battlefield environments without special training. This technology goes beyond normal evolutionary development approaches because it breaks the existing paradigms of the diagnostic industry by demonstrating the technical feasibility of detecting a non-nucleic acid target using a nucleic acid detector system.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government