PARATHYROID IMAGING BY RADIOLABELED MONOCLONAL ANTIBODY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
4745
Agency Tracking Number:
4745
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4649 Le Bourget Dr, St Louis, MO, 63134
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Charles Benton
Principal Investigator
(314) 727-8255
Business Contact:
() -
Research Institute:
n/a
Abstract
THE GOAL OF THIS PROJECT IS TO DEVELOP A MONOCLONAL ANTIBODY-BASED IMAGING REAGENT CAPABLE VISUALIZING HUMAN PARATHYROIDGLANDS. THE STUDY WILL BE DIRECTED AT ISOLATION AND CHARACTERIZATION OF HUMAN PARATHYROID-SPECIFIC MOUSE MONOCLONAL ANTIBODIES AND PRELIMINARY ANALYSIS OF THEIR TARGET ANTIGENS. AS THE CLASS AND SUBCLASS OF ANTIBODIES WILL LIKELY INFLUENCE IMAGING PROPERTIES, VARIANTS OF HYBRIDOMAS WILL BE SELECTED BY FLUORESCENCE-ACTIVATED CELL SORTERS THAT SECRETE IMMUNOGLOBULINS OF DIFFERENT IGG SUBCLASSES AND IGM. THESE ANTIBODIES WILL BE TESTED FOR LOCALIZATION OF HUMAN PARATHYROID FRAGMENTS IN NUDE MICE. FUTURE PHASE II STUDIES WILL FOCUS ON THE IMAGING PARAMETERSOF THESE VARIANT ANTIBODIES IN LARGE ANIMALS, SUCH AS DOGS OR MONKEYS, TO SELECT THE OPTIMAL CONDITIONS FOR IMAGING IN HUMANS.

* information listed above is at the time of submission.

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