DRUG SCREENING: HIGH-SPEED CAPILLARY GAS CHROMATOGRAPHY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$352,702.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11391
Agency Tracking Number:
11391
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
10633 Richmond Ave Ste 170, Houston, TX, 77042
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
MAJOR PROBLEMS ASSOCIATED WITH THE SCREENING OF BODY FLUIDS FOR DRUGS OF ABUSE INCLUDE THE RELATIVELY LOW SPEED OF ANALYSIS AND THE OFTEN POOR RELIABILITY OF THE GENERATED DATA. CAPILLARY GAS CHROMATOGRAPHY IS ACKNOWLEDGED TO BE SUPERIOR IN PERFORMANCE TO THIN-LAYER CHROMATOGRAPHY AND IMMUNOASSAYS, BUT IT IS GENERALLY TOO SLOW TO BE OF VALUE IN THE SCREENING OF LARGE NUMBERS OF SAMPLES. IONICS RESEARCH, INC., PLANS TO DEVELOP A HIGH-SPEED CAPILLAR GAS CHROMATOGRAPH THAT WOULD BE SUITABLE FOR THE ANALYSIS OF DRUGS OF ABUSE IN JUST A FEW SECONDS. THE HEART OF THE NEW INSTRUMENT WOULD BE A MICROBORE COLUMN WITH AN INTERNAL DIAMETER OF 50MUM OR LESS. TO TAKE ADVANTAGE OF THE ULTIMATE PERFORMANCE OF THIS COLUMN, A REVOLUTIONARY INLET SYSTEM AND LOW-DEAD-VOLUME WILL BE DEVELOPED. HIGH-SPEED CHROMATOGRAOPHY WITH A CONCENTRATION-DEPENDENT DETECTOR HAS THE ADDED ADVANTAGE OF A GREATLY IMPROVED DETECTION LIMIT, SO VERY SMALL SAMPLESOF BODY FLUIDS WOULD BE ADEQUATE FOR ANALYSIS. A PROTOTYPE INSTRUMENT WILL BE CONSTRUCTED AND EVALUATED FOR THE DETERMINATION OF AMPHETAMINES, BARBITURATES, OPIOIDS, AND OTHER DRUGS OF ABUSE IN BODY FLUIDS.

* information listed above is at the time of submission.

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