Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0109700
Agency Tracking Number: 0109700
Amount: $99,647.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
2472 Bolsover, Suite 255, Houston, TX, 77005
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 J. Albert Schultz
 (713) 522-9880
Business Contact
 J Albert Schultz
Title: President
Phone: (713) 522-9880
Email: al@ionwerks.com
Research Institution
This Small Business Innovation Research Phase I (SBIR) project will test Cesium Iodide cluster ion beams as an alternative to lasers for desorbing bioions from a MALDI ((Matrix Assisted Laser Desorption Ionization) matrix. This offers the possiblity of performing the post source decay tandem mass spectrometry on an event by event basis, making possible the application of coincidence techniques which allow specific correlations to be made between metastable parent ions and their ionic fragments. This is an anaolgy to what has already been demonstrated for 252Cf fission fragment plasma desorption mass spectroscopy of bioions. Thus post source decay becomes a true MS/MS technique. There is also the possiblity that the use of cluster ions can increase the fragmentation and the degree of metastability of the desorbed bioions compared to using a laser. If so, the cluster deorption technique may be more suitable than lasers for imaging biomolecules on materials such as polymers or tissue slices. This Phase I project proposes to develop a cheap and reliable cluster ion source for MALDI. At the conclusion of Phase II, this ion source could be combined with a curve field reflector TOF mass spectrometer and marketed as a new approach to post source decay measurements. The commercial applications of this project will be in the area of biomolecular mass spectrometry.

* Information listed above is at the time of submission. *

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