INTELLIGENT MICROSCOPE WORKSTATION FOR CANCER DIAGNOSIS

Award Information
Agency:
Department of Health and Human Services
Amount:
$500,000.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1993
Phase:
Phase II
Agency Tracking Number:
16449
Solicitation Topic Code:
N/A
Small Business Information
Kensal Consulting
5055 E Broadway, Suite C214, Tucson, AZ, 85711
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Preston, Kendall, Jr
 Principal Investigator
 (602) 745-8250
Business Contact
 1 R43 CA56511-01
Phone: () -
Research Institution
N/A
Abstract
DURING THE 1984-1990 ACADEMIA, CARNEGIE MELLON UNIVERSITY AND THE UNIVERSITY OF SOUTHERN CALIFORNIA, USING THE $180,000 COULTER BIOMEDICAL RESEARCH ROBOT MICROSCOPE, THE DIFF3/50, INTERFACED TO A $80,000 INTERDATA MODEL 3230 COMPUTER, CONDUCTED RESEARCH UNDER A SERIES OF NIH GRANTS CUMULATIVELY FUNDED AT OVER $1 MILLION WHICH ACHIEVED INTELLIGENT PERFORMANCE IN SUBTYPING FOLLICULAR LYMPHOMAS. THE RESULTING SYSTEM, WHEN TEAMED WITH THE EXPERT VISUAL SKILLS OF THE PATHOLOGIST IN LOCATING FOLLICLES, ACHIEVED PERFORMANCE FAR EXCEEDING THAT OF EITHER THE ROBOT OR THE PATHOLOGIST ACTING ALONE. AT THE SAME TIME PIC FUNDED THE REDUCTION TO PRACTICE OF A PROPRIETARY $5,000 COMPUTERIZED CAMERA FOR DIGITAL MICROSCOPY HAVING A NETWORK INTERFACE TO PERSONAL COMPUTERS. USING THIS CAMERA AND PC-BASED IMAGE ANALYSIS SOFTWARE BY KENSAL CONSULTING IN A JOINT PROJECT WITH THE DEPARTMENT OF PATHOLOGY, UNIVERSITY OF TEXAS, PIC REPRODUCED IN ONE DAY THE RESULTS ACHIEVED BY CMU/USC. SINCE THE PATIENT SAMPLE WAS TOO SMALL TO DRAW STATISTICAL CONCLUSIONS, IT IS THEREFORE THE PURPOSE OF THIS PROJECT TO CONDUCT A DEFINITIVE STUDY OF 100-200 PATIENTS (FIVE TIMES THAT OF THE CMU/USC STUDY), AND TO SIMULTANEOUSLY DETERMINE THE ROBUSTNESS OF THE ALGORITHMIC ENVIRONMENT WITH REGARD TO RESOLUTION, MAGNIFICATION, COLOR, ETC. THE AIM OF THIS PHASE I RESEARCH WOULD BE TO REDUCE TO PRACTICE AND EXHAUSTIVELY TEST THE CMU/USC CANCER DIAGNOSIS WHICH COULD BE MANUFACTURED COMMERCIALLY AND SOLD FOR WIDESPREAD USE NATIONWIDE DURING PHASE III AT A PRICE OF $15,000 OR LESS PER UNIT.

* information listed above is at the time of submission.

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