THERMOPHILIC MICROORGANISMS AS SOURCE OF HEAT STABLE OXIDASE AND PEROXIDASE

Award Information
Agency:
Department of Defense
Amount:
$236,120.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
Army
Award Year:
1989
Phase:
Phase II
Agency Tracking Number:
6016
Solicitation Topic Code:
N/A
Small Business Information
J. K. Research
210 S Wallace, Bozeman, MT, 59715
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Dr Joan Combie
 (406) 587-7978
Business Contact
Phone: () -
Research Institution
N/A
Abstract
ENZYMES OF INTEREST IN CHEMICAL/BIOLOGICAL DEFENSE, PARTICULALY OXIDASES AND PEROXIDASES, WOULD BE MORE USEFUL IF THEY COULD WITHSTAND HIGH TEMPERATURES AND HAD A LONGER SHELF LIFE. THERMALLY LABILE FORMS NOW AVAILABLE COULD BE SYNTHETICALLY STABILIZED BUT THIS WOULD BE EXPENSIVE. MICROORGANISMS EXISTING IN HIGH TEMPERATURE HABITATS SURVIVE SUCH CONDITIONS BECAUSE THEY PRODUCE HEAT STABLE ENZYMES. THE VARIED ENVIRONMENTAL EXTREMES OF A NEARBY GEOTHERMAL REGION PROVIDE AN UNPARALLELED OPPORTUNITY TO SCREEN BACTERIA, FUNGI AND ALGAE FROM THERMALLY STABLE OXIDASES AND PEROXIDASES. ONCE ISOLATED, AN ATTEMPT WILL BE MADE TO INCREASE ENZYME PRODUCTION IN THE MOST PROMISING ORGANISMS BY MANIPULATION OF AERATION, TEMPERATURE AND CHEMICAL INDUCERS.

* information listed above is at the time of submission.

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