THERMOPHILIC MICROORGANISMS AS SOURCE OF HEAT STABLE OXIDASE AND PEROXIDASE

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$236,120.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
6016
Agency Tracking Number:
6016
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
210 S Wallace, Bozeman, MT, 59715
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Joan Combie
(406) 587-7978
Business Contact:
() -
Research Institution:
n/a
Abstract
ENZYMES OF INTEREST IN CHEMICAL/BIOLOGICAL DEFENSE, PARTICULALY OXIDASES AND PEROXIDASES, WOULD BE MORE USEFUL IF THEY COULD WITHSTAND HIGH TEMPERATURES AND HAD A LONGER SHELF LIFE. THERMALLY LABILE FORMS NOW AVAILABLE COULD BE SYNTHETICALLY STABILIZED BUT THIS WOULD BE EXPENSIVE. MICROORGANISMS EXISTING IN HIGH TEMPERATURE HABITATS SURVIVE SUCH CONDITIONS BECAUSE THEY PRODUCE HEAT STABLE ENZYMES. THE VARIED ENVIRONMENTAL EXTREMES OF A NEARBY GEOTHERMAL REGION PROVIDE AN UNPARALLELED OPPORTUNITY TO SCREEN BACTERIA, FUNGI AND ALGAE FROM THERMALLY STABLE OXIDASES AND PEROXIDASES. ONCE ISOLATED, AN ATTEMPT WILL BE MADE TO INCREASE ENZYME PRODUCTION IN THE MOST PROMISING ORGANISMS BY MANIPULATION OF AERATION, TEMPERATURE AND CHEMICAL INDUCERS.

* information listed above is at the time of submission.

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