CONTACT X-RAY MICROSCOPY PROMISES UNIQUE CAPABILITIES THAT ARE NOT POSSIBLE WITH ALTERNATE MICROSCOPIES, INCLUDING IN VIVO MICROSTRUCTURE IMAGING OF LIVE, UNSTAINED SPECIMENS, AND LOCALIZATION AND IDENTIFICATION OF MINUTE CONCENTRATIONSOF CHEMICAL

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4939
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Jaycor
11011 Torreyana Road, Po Box 85154, San Diego, CA, 92138
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DR FRANK J WESSEL
 PRINCIPAL INVESTIGATOR
 (619) 453-6580
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CONTACT X-RAY MICROSCOPY PROMISES UNIQUE CAPABILITIES THAT ARE NOT POSSIBLE WITH ALTERNATE MICROSCOPIES, INCLUDING IN VIVO MICROSTRUCTURE IMAGING OF LIVE, UNSTAINED SPECIMENS, AND LOCALIZATION AND IDENTIFICATION OF MINUTE CONCENTRATIONSOF CHEMICAL ELEMENTS WITH A RESOLUTION APPROACHING 5 NANOMETERS (50A). HOWEVER, THE CURRENT DEVELOPMENTAL STATUSOF X-RAY SOURCES IS LIMITED, MAKING THESE CAPABILITIES DIFFICULT TO REALIZE OF UNACHIEVABLE. THE OBJECTIVES OF THISPROGRAM ARE TO REMOVE THESE LIMITATIONS BY DEVELOPING A UNIQUE PULSED-PLASMA X-RAY SOURCE, SPECIFICALLY OPTIMIZED FOR X-RAY IMAGING IN BIOMEDICAL APPLICATIONS. THE GENERAL FEATURES OF THIS SOURCE ARE COMPACT SIZE, HIGH-INTENSITY, TUNABLE X-RAY OUTPUT, HIGH-REPETITION RATE, AND SIMPLICITY OF OPERATION. IF SUCCESSFUL, THIS PROGRAM WILL DEMONSTRATE THE UTILITY OF THESE X-RAY SOURCES FOR BIOMEDICAL MICRO- SCOPY, WITH PARTICULAR EMPHASIS GIVEN TOWARD IMAGING SAMPLE SPECIMENS OF SPECIFIC IMPORTANCE TO CANCER RESEARCH. DURINGPHASE I, THE X-RAY SOURCE WILL BE DESIGNED AND AN EXPERIMEN-TAL PLAN SPECIFIED TO CHARACTERIZE AND EVALUATE THE SOURCE PERFORMANCE FOR MICROSCOPY. DURING PHASE II, THE SOURCE WILL BE ASSEMBLED AND THE EXPERIMENTAL PLAN EXECUTED. THE BENEFITS OF THIS RESEARCH WILL BE TO ELIMINATE NUMEROUS TECHNICAL IMPEDIMENTS TO CONTACT X-RAY MICROSCOPY AND EXPEDITE THE COMMERCIAL AVAILABILITY OF THIS TECHNOLOGY TO BIOMEDICAL RESEARCH SCIENTISTS.

* information listed above is at the time of submission.

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