JEFFERIES ASSOCIATES WISHES TO APPLY ITS PROPRIETARY STABILIZATION TECHNOLOGY TO THE PROBLEM OF RAPID LIPOSOME UPTAKE BY THE RES.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$48,500.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3071
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Jefferies Associates
208 East Lake Avenue, Baltimore, MD, 21212
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
STEVEN R. JEFFERIES
PRINCIPAL INVESTIGATOR
(301) 323-3030
Business Contact:
() -
Research Institution:
n/a
Abstract
JEFFERIES ASSOCIATES WISHES TO APPLY ITS PROPRIETARY STABILIZATION TECHNOLOGY TO THE PROBLEM OF RAPID LIPOSOME UPTAKE BY THE RES. WE BELIEVE THAT, WITH PROPER SURFACE MODIFICATION OF THE LIPOSOME MICROCARRIER, UTILIZING SURFACE BINDING OF A SPECIFIC MEMBRANE-BOUND GLYCOPROTEIN, THE CIRCULATORY HALF-LIFE OF INJECTABLE LIPOSOMES CAN BE INCREASED SIGNIFICANTLY. THIS HYPOTHESIS WILL BE TESTED BY IN VITRO MACROPHAGE UPTAKE OF ALTERED LIPOSOMES AND A DIRECT COMPARISON TO CONTROL PHOSPHOLIPID VESICLES.

* information listed above is at the time of submission.

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