JEFFERIES ASSOCIATES WISHES TO APPLY ITS PROPRIETARY STABILIZATION TECHNOLOGY TO THE PROBLEM OF RAPID LIPOSOME UPTAKE BY THE RES.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3071
Amount: $48,500.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Jefferies Associates
208 East Lake Avenue, Baltimore, MD, 21212
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 STEVEN R. JEFFERIES
 PRINCIPAL INVESTIGATOR
 (301) 323-3030
Business Contact
Phone: () -
Research Institution
N/A
Abstract
JEFFERIES ASSOCIATES WISHES TO APPLY ITS PROPRIETARY STABILIZATION TECHNOLOGY TO THE PROBLEM OF RAPID LIPOSOME UPTAKE BY THE RES. WE BELIEVE THAT, WITH PROPER SURFACE MODIFICATION OF THE LIPOSOME MICROCARRIER, UTILIZING SURFACE BINDING OF A SPECIFIC MEMBRANE-BOUND GLYCOPROTEIN, THE CIRCULATORY HALF-LIFE OF INJECTABLE LIPOSOMES CAN BE INCREASED SIGNIFICANTLY. THIS HYPOTHESIS WILL BE TESTED BY IN VITRO MACROPHAGE UPTAKE OF ALTERED LIPOSOMES AND A DIRECT COMPARISON TO CONTROL PHOSPHOLIPID VESICLES.

* information listed above is at the time of submission.

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