PROSTHESIS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4748
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
715 North Shore Drive, Milford, DE, 19963
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 CHARLES C CHEN
 PRINCIPAL INVESTIGATOR
 (302) 422-2161
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE RECONSTRUCTION OF THE BREAST FOLLOWING ABLATIVE SURGERY HAS BECOME AN INCREASINGLY FREQUENT SURGICAL PROCEDURE. THEDEVELOPMENT AND USE OF SILICONE GEL AND SALINE-FILLED SILASTIC IMPLANTS HAVE CONTRIBUTED TO THE INCREASING FREQUENCY OF THIS PROCEDURE. THICKENING AND CONTRACTURE OF THE FIBROUS CAPSULE SURROUNDING THE SILASTIC IMPLANT, HOWEVER, REMAINS A MAJOR POSTSURGICAL PROBLEM. ANIMAL STUDIES, AS WELL AS HISTOLOGIC EVALUATION OF HUMAN CAPSULE SEGMENTS, HAVE REVEALED THE NATURE OF THIS FIBROPROLIFERATIVE RESPONSE. LEAKAGE OR "BLEEDING" OF SILICONE GEL FROM SILASTIC BREAST IMPLANTS APPEARS TO BE A MAJOR CAUSE OF THIS INFLAMMATORY RESPONSE, WHICH ULTIMATELY RESULTS IN A CONSTRICTIVE FIBROSIS SURROUNDING SILICONE-GEL IMPLANTS. THE USE OF LESS REACTIVE FILLING SUBSTANCES MAY OFFER THE POSSIBILITY FOR THE PREVENTION OF CAPSULAR CONTRACTURE. AS SUCH, THIS PROJECT WILL EMPLOY A FEASIBILITY STUDY OF BALLOON-TYPE IMPLANTS WITH A HIGHLY BIOCOMPATIBLE FILLING SUBSTANCE. IT IS ANTICIPATED THAT A BREAST PROSTHESIS OF THIS TYPE WILL MINIMIZE THICKENING AND CONTRACTURE OF THE FIBROUS CAPSULE SURROUNDING THE PROSTHESIS.

* Information listed above is at the time of submission. *

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