PROSTHESIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
4748
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Jefferies Associates
715 North Shore Drive, Milford, DE, 19963
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
CHARLES C CHEN
PRINCIPAL INVESTIGATOR
(302) 422-2161
Business Contact:
() -
Research Institution:
n/a
Abstract
THE RECONSTRUCTION OF THE BREAST FOLLOWING ABLATIVE SURGERY HAS BECOME AN INCREASINGLY FREQUENT SURGICAL PROCEDURE. THEDEVELOPMENT AND USE OF SILICONE GEL AND SALINE-FILLED SILASTIC IMPLANTS HAVE CONTRIBUTED TO THE INCREASING FREQUENCY OF THIS PROCEDURE. THICKENING AND CONTRACTURE OF THE FIBROUS CAPSULE SURROUNDING THE SILASTIC IMPLANT, HOWEVER, REMAINS A MAJOR POSTSURGICAL PROBLEM. ANIMAL STUDIES, AS WELL AS HISTOLOGIC EVALUATION OF HUMAN CAPSULE SEGMENTS, HAVE REVEALED THE NATURE OF THIS FIBROPROLIFERATIVE RESPONSE. LEAKAGE OR "BLEEDING" OF SILICONE GEL FROM SILASTIC BREAST IMPLANTS APPEARS TO BE A MAJOR CAUSE OF THIS INFLAMMATORY RESPONSE, WHICH ULTIMATELY RESULTS IN A CONSTRICTIVE FIBROSIS SURROUNDING SILICONE-GEL IMPLANTS. THE USE OF LESS REACTIVE FILLING SUBSTANCES MAY OFFER THE POSSIBILITY FOR THE PREVENTION OF CAPSULAR CONTRACTURE. AS SUCH, THIS PROJECT WILL EMPLOY A FEASIBILITY STUDY OF BALLOON-TYPE IMPLANTS WITH A HIGHLY BIOCOMPATIBLE FILLING SUBSTANCE. IT IS ANTICIPATED THAT A BREAST PROSTHESIS OF THIS TYPE WILL MINIMIZE THICKENING AND CONTRACTURE OF THE FIBROUS CAPSULE SURROUNDING THE PROSTHESIS.

* information listed above is at the time of submission.

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