Chloroplast Genetic Engineering to Produce Diagnostic Antigens and Vaccines

Award Information
Agency:
Department of Defense
Amount:
$729,998.00
Program:
SBIR
Contract:
W81XWH-06-C-0009
Solitcitation Year:
2005
Solicitation Number:
2005.2
Branch:
Army
Award Year:
2006
Phase:
Phase II
Agency Tracking Number:
A052-175-1017
Solicitation Topic Code:
A05-175
Small Business Information
KUEHNLE AGROSYSTEMS COMPANY, LLC
2800 Woodlawn Drive, Honolulu, HI, 96822
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
142296982
Principal Investigator
 Michele Champagne
 Senior Researcher
 (808) 753-5084
 kasllc@hawaii.rr.com
Business Contact
 Gordon Wallace
Title: President
Phone: (808) 753-3170
Email: kasllc@hawaii.rr.com
Research Institution
N/A
Abstract
Plant chloroplasts are capable of producing significant quantities of high quality bioengineered proteins with biomedical applications. Improving the commercial supply of diagnostic antigens and vaccines through use of our pliable expression platform will provide an important technological advance compared with the current mammalian and microbial cell culture platforms. Our innovative approach combines a next-generation plant platform, for rapid line production, with established downstream processing, and a novel technology that permits site-directed insertion of one or more transgenes in chloroplasts. This platform advance has the potential for significant production of antigens, such as for the hantavirus, in contained, biosecure facilities under conditions of Good Manufacturing Practice. Production of hantaviral proteins using the technical enabling strategies developed in Phase I for our target platform is anticipated to meet the proposed Phase II goal of applying the technology collaboratively to produce sufficient quality antigens for diagnostic and immunogenicity assays.

* information listed above is at the time of submission.

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